2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Type II TRK inhibitor 1

Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Type II TRK inhibitor 1 Chemical Structure

Type II TRK inhibitor 1 Chemical Structure

CAS No. : 2937543-72-9

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Type II TRK inhibitor 1 Related Antibodies

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Description

Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively[1]. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

TrkA

 

TrkC

 

In Vitro

Type II TRK inhibitor 1 (compound 7b) (3.1-800 nM; 2 h) inhibits the phosphorylation of TRKA, PLCγ1, and ERK[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Type II TRK inhibitor 1 Related Antibodies

Western Blot Analysis[1]

Cell Line: Ba/F3 engineered cells harboring CD74-TRKA, CD74-TRKAG667C, and CD74-TRKAG595R
Concentration: 0 nM, 3.1 nM, 12.5 nM, 50 nM, 200 nM, 800 nM
Incubation Time: 24 hours
Result: Decreased the protein level of p-TRKA, p-PLCγ1, p-ERK in cells.
Molecular Weight

670.68

Formula

C35H33F3N8O3
CAS No.
SMILES

CN(CCN1)C2=NN3C(C=C2)=NC=C3C#CC4=CC(OCCCCC1=O)=CC(C(NC5=CC(N6C=C(C)N=C6)=CC(C(F)(F)F)=C5)=O)=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Type II TRK inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Type II TRK inhibitor 12937543-72-9Trk ReceptorTropomyosin related kinase receptorTRK fusion proteinantiproliferative activityBa/F3 cellsInhibitorinhibitorinhibit

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