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CCR3+antagonist

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By Targets:	5-HT Receptor (1) CCR (10) Cytochrome P450 (1) Dopamine Receptor (1) Endogenous Metabolite (1) Reference Standards (2) Serotonin Transporter (1) Thymidylate Synthase (2)
By Research Areas:	Cancer (2) Endocrinology (4) Inflammation/Immunology (10) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103363

SB-328437 3 Publications Verification	CCR Thymidylate Synthase	Inflammation/Immunology Cancer
SB-328437 is a potent, selective non-peptide *CCR3* antagonist with an IC₅₀ of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006)-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases ^[3].

HY-103361

SB297006 1 Publications Verification	CCR	Neurological Disease Endocrinology
SB297006 is a *CCR3* antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

HY-107051

GW 766994 2 Publications Verification GW 994	CCR	Inflammation/Immunology Endocrinology
GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research .

HY-U00331

CCR3 antagonist 1 1 Publications Verification	CCR	Inflammation/Immunology Endocrinology
CCR3 antagonist 1 is a potent antagonist of *CCR3*, used for the research of immunologic and inflammatory diseases.

HY-19501

DPC-168	CCR	Inflammation/Immunology
DPC-168 is an orally effective *CCR3* antagonist (IC₅₀ = 41 nM). DPC-168 exhibits a significant ability to inhibit eosinophil chemotaxis and pulmonary inflammation. DPC-168 can be used for research on airway inflammation .

HY-177312

CCR3 antagonist 2	CCR	Inflammation/Immunology
CCR3 antagonist 2 (example 66) is a *CCR3* antagonist that can be used for the study of inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease .

HY-N10397

Maceneolignan H	CCR	Inflammation/Immunology
Maceneolignan H (Compound 8) is a neolignane compound isolated from the arils of Myristica fragrans. Maceneolignan H is a selective CCR3 antagonist (EC₅₀ = 1.4 μM). Maceneolignan H has the potential for the research of allergic diseases .

HY-111198

YM-355179 fumarate	Endogenous Metabolite	Inflammation/Immunology
YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC₅₀ values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC₅₀ The values are 8.0 nM, 24 nM and 29 nM respectively .

HY-107051R

GW 766994 (Standard) GW 994 (Standard)	Reference Standards CCR	Inflammation/Immunology Endocrinology
GW 766994 (Standard) (GW 994 (Standard)) is the analytical standard of GW 766994 (HY-107051). This product is intended for research and analytical applications. GW 766994 (GW 994) is an orally active and specific chemoK_ine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research .

HY-182735

BMS-570520	CCR Cytochrome P450 5-HT Receptor Dopamine Receptor Serotonin Transporter	Inflammation/Immunology
BMS-570520 is an orally bioavailable *CCR3* antagonist with an IC₅₀ of 1.9 nM against *hCCR3* and an IC₅₀ of 1300 nM against hCYP2D6. BMS-570520 inhibits CYP2D6, but shows low activity against off-target G protein-coupled receptors, biogenic amine transporters, and the hERG potassium channel. BMS-570520 regulates chemotaxis, calcium mobilization, and anti-inflammatory pathways. BMS-570520 can be used in research related to asthma, allergic rhinitis, and contact dermatitis .

HY-103363R

SB-328437 (Standard)	Reference Standards CCR Thymidylate Synthase	Inflammation/Immunology Cancer
SB-328437 (Standard) is the analytical standard of SB-328437 (HY-103363). This product is intended for research and analytical applications. SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC₅₀ of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006)-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases ^[3].

Maceneolignan H	Structural Classification Classification of Application Fields Lignans Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt. Inflammation/Immunology Disease Research Fields Source Classification	CCR
Maceneolignan H (Compound 8) is a neolignane compound isolated from the arils of Myristica fragrans. Maceneolignan H is a selective CCR3 antagonist (EC₅₀ = 1.4 μM). Maceneolignan H has the potential for the research of allergic diseases .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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CCR3+antagonist

Inhibitors & Agonists

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