2. GPCR/G Protein
    Immunology/Inflammation
  3. CCR
  4. GW 766994

GW 766994  (Synonyms: GW 994)

Cat. No.: HY-107051 Purity: 99.73%
COA Handling Instructions

GW 766994 (GW 994) est un antagoniste du récepteur de chimiokine-3 (CCR3) qui est oralement actif et spécifique. GW 766994 a le potentiel pour la recherche sur l'asthme et la bronchite à éosinophiles.

GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.

For research use only. We do not sell to patients.

GW 766994 Chemical Structure

GW 766994 Chemical Structure

CAS No. : 408303-43-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 407 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 407 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 370 In-stock
Estimated Time of Arrival: December 31
10 mg USD 590 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1880 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2980 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE GW 766994

View All CCR Isoform Specific Products:

View All Isoforms
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research[1][2].

IC50 & Target[1]

CCR3

7.86 (pKi)

In Vitro

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis[1]. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

451.35

Appearance

Solid

Formula

C21H24Cl2N4O3
CAS No.
SMILES

NC(C(C=C1)=CC=C1CNC(NC[[email protected]](OCC2)CN2CC3=CC(Cl)=C(Cl)C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 56 mg/mL (124.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2156 mL 11.0779 mL 22.1558 mL
5 mM 0.4431 mL 2.2156 mL 4.4312 mL
10 mM 0.2216 mL 1.1078 mL 2.2156 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GW 766994408303-43-5GW 994GW766994GW-766994GW994GW-994CCRCC chemokine receptorInhibitorinhibitorinhibit

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