1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. GW 766994

GW 766994 (Synonyms: GW 994)

Cat. No.: HY-107051 Purity: 99.53%
Handling Instructions

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has has the potential for asthma and eosinophilic bronchitis treatment.

For research use only. We do not sell to patients.

GW 766994 Chemical Structure

GW 766994 Chemical Structure

CAS No. : 408303-43-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has has the potential for asthma and eosinophilic bronchitis treatment.

IC50 & Target[1]

CCR3

7.86 (pKi)

In Vitro

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis[1]. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons[2].

Molecular Weight

451.35

Formula

C₂₁H₂₄Cl₂N₄O₃

CAS No.

408303-43-5

SMILES

NC(C(C=C1)=CC=C1CNC(NC[[email protected]](OCC2)CN2CC3=CC(Cl)=C(Cl)C=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 56 mg/mL (124.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2156 mL 11.0779 mL 22.1558 mL
5 mM 0.4431 mL 2.2156 mL 4.4312 mL
10 mM 0.2216 mL 1.1078 mL 2.2156 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

GW 766994GW 994GW766994GW-766994GW994GW-994CCRCC chemokine receptorInhibitorinhibitorinhibit

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Product name:
GW 766994
Cat. No.:
HY-107051
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