1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. GW 766994

GW 766994 (Synonyms: GW 994)

Cat. No.: HY-107051 Purity: 99.53%
Handling Instructions

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.

For research use only. We do not sell to patients.

GW 766994 Chemical Structure

GW 766994 Chemical Structure

CAS No. : 408303-43-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.

IC50 & Target[1]

CCR3

7.86 (pKi)

In Vitro

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis[1]. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons[2].

Molecular Weight

451.35

Formula

C₂₁H₂₄Cl₂N₄O₃

CAS No.

408303-43-5

SMILES

NC(C(C=C1)=CC=C1CNC(NC[[email protected]](OCC2)CN2CC3=CC(Cl)=C(Cl)C=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 56 mg/mL (124.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2156 mL 11.0779 mL 22.1558 mL
5 mM 0.4431 mL 2.2156 mL 4.4312 mL
10 mM 0.2216 mL 1.1078 mL 2.2156 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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GW 766994
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HY-107051
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