408303-43-5
408303-43-5
Chemical Structure
GW 766994
Synonym(s): GW 994
- CAS No.: 408303-43-5
- Formula:C21H24Cl2N4O3
- Molecular Weight:451.35
IUPAC Name: (S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide
InChIKey: GPLUUMAKBFSDIE-KRWDZBQOSA-N
SMILES: NC(C(C=C1)=CC=C1CNC(NC[C@H](OCC2)CN2CC3=CC(Cl)=C(Cl)C=C3)=O)=O
Biological Activity: GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research[1][2].
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GW 766994 | 98.73% | GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research. | ||||||||||||||||||||
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GW 766994 (Standard) | GW 766994 (Standard) (GW 994 (Standard)) is the analytical standard of GW 766994 (HY-107051). This product is intended for research and analytical applications. GW 766994 (GW 994) is an orally active and specific chemoKine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research. | |||||||||||||||||||||
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References
- [1]. Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16. [Content Brief]
- [2]. Zhu C, et al. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978. [Content Brief]
Keywords
