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Cat. No.: HY-19501

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DPC-168

DPC-168 is an orally effective CCR3 antagonist (IC₅₀ = 41 nM). DPC-168 exhibits a significant ability to inhibit eosinophil chemotaxis and pulmonary inflammation. DPC-168 can be used for research on airway inflammation.

For research use only. We do not sell to patients.

CAS No.: 275810-55-4
Formula: C₂₈H₃₆FN₃O₂
Molecular Weight:465.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DPC-168 Chemical Structure

CAS No.: 275810-55-4

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Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All CCR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	2 nM Compound: 1, DPC168	Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins	[PMID: 17418570]
CHO	IC₅₀	2 nM Compound: 2a	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	[PMID: 18096386]
CHO	IC₅₀	2 nM Compound: 32	Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells	[PMID: 15771462]
CHO	IC₅₀	54 nM Compound: 1, DPC168	Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins	[PMID: 17418570]

Chemical Information

CAS No. 275810-55-4
Molecular Weight 465.60
Formula C₂₈H₃₆FN₃O₂
SMILES

O=C(N[C@H]1[C@H](CN2C[C@H](CC3=CC=C(F)C=C3)CCC2)CCCC1)NC4=CC=CC(C(C)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. D'Elios M M, et al. Interfering with chemokines and chemokine receptors as potential new therapeutic strategies[J]. Expert Opinion on Therapeutic Patents, 2008, 18(3): 309-325.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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