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Cd40 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Cytochrome P450 (1) Fluorescent Dye (1) Interleukin Related (1) JAK (1) NF-κB (1) TNF Receptor (8)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (9) Metabolic Disease (2)

11

Inhibitors & Agonists

1

Fluorescent Dye

1

Inhibitory Antibodies

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

BIO8898	TNF Receptor Apoptosis	Metabolic Disease
BIO8898 is a potent *CD40-CD154* inhibitor. BIO8898 inhibits soluble CD40L binding to CD40-Ig with an IC₅₀ value of 25 µM. BIO8898 inhibits CD40L-induced apoptosis.

HY-122663

(Rac)-BIO8898

TNF Receptor Cancer

(Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits CD154 binding to CD40-Ig with an IC₅₀ of 25 μM.

DRI-C21041 (DIEA)	TNF Receptor	Inflammation/Immunology
DRI-C21041 DIEA is a *CD40/CD40L* interaction inhibitor, with an IC₅₀ of 0.31 μM. DRI-C21041 DIEA inhibits the immune response induced by alloantigen.

DRI-C21041	TNF Receptor	Inflammation/Immunology
DRI-C21041 is a *CD40/CD40L* interaction inhibitor, with an IC₅₀ of 0.31 μM. DRI-C21041 inhibits the immune response induced by alloantigen.

SMI 6860766	TNF Receptor	Metabolic Disease Inflammation/Immunology
SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation.

DRI-C25441	TNF Receptor	Inflammation/Immunology
DRI-C25441 is a potent blocker of CD40 and CD40L interaction, with an IC₅₀ of 0.36 μM. DRI-C25441 can inhibit the immune response induced by alloantigen.

Mordant brown 1	Fluorescent Dye	Others
Mordant brown 1, a naphthalenesulphonic acid derivative, is an azo dye. Mordant brown 1 is also an effective and specific inhibitor of CD40-CD154 costimulatory protein-protein interaction.

DRI-C21045 1 Publications Verification	TNF Receptor	Inflammation/Immunology
DRI-C21045 (compound 10) is a potent and selective inhibitor of the *CD40-CD40L* costimulatory protein-protein interaction (PPI) with an IC₅₀ of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC₅₀s of 17.1 µM and 4.5 µM, respectively.

TRAF-STOP inhibitor 6877002	TNF Receptor NF-κB	Inflammation/Immunology Cardiovascular Disease
TRAF-STOP inhibitor 6877002, is a selective inhibitor of *CD40-TRAF6* interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques.

BMS-986202	JAK Cytochrome P450	Inflammation/Immunology
BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC₅₀ value of 0.19 nM and a K_i of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC₅₀ value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium.

Tyrphostin A1 Tyrphostin 1; AG9	Interleukin Related	Inflammation/Immunology
Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.

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Cat. No.	Product Name	Target	Research Area

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