1. Immunology/Inflammation
  2. Interleukin Related
  3. Tyrphostin A1

Tyrphostin A1 (Synonyms: Tyrphostin 1; AG9)

Cat. No.: HY-16668 Purity: 99.50%
Handling Instructions

Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.

For research use only. We do not sell to patients.

Tyrphostin A1 Chemical Structure

Tyrphostin A1 Chemical Structure

CAS No. : 2826-26-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
10 mg USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 242 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. IC50 value: Target: IL-12 production inhibitor Addition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation of NF-κB to the nucleus, and reduces the activation of IL-12 p40 gene. In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells. In addition, treatment of SJL/J mice with A1 results in attenuation of experimental allergic encephalomyelitis (EAE) [1]. Tyrphostin A1 is a much weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase), and therefore often used to differentiate TK-mediated effects of tyrphostins from other non-specific effects [2].

IC50 & Target

IL-12

 

Molecular Weight

184.19

Formula

C₁₁H₈N₂O

CAS No.
SMILES

N#C/C(C#N)=C\C1=CC=C(OC)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (542.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4292 mL 27.1459 mL 54.2918 mL
5 mM 1.0858 mL 5.4292 mL 10.8584 mL
10 mM 0.5429 mL 2.7146 mL 5.4292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (11.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.50%

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Keywords:

Tyrphostin A1Tyrphostin 1 AG9Tyrphostin A 1Tyrphostin A-1Tyrphostin1Tyrphostin-1AG9AG 9AG-9Interleukin RelatedILInhibitorinhibitorinhibit

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Tyrphostin A1
Cat. No.:
HY-16668
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