2826-26-8
2826-26-8
Chemical Structure
Tyrphostin A1
Synonym(s): Tyrphostin 1; AG9
- CAS No.: 2826-26-8
- Formula:C11H8N2O
- Molecular Weight:184.19
IUPAC Name: 2-(4-methoxybenzylidene)malononitrile
InChIKey: UOHFCPXBKJPCAD-UHFFFAOYSA-N
SMILES: N#C/C(C#N)=C\C1=CC=C(OC)C=C1
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tyrphostin A1 | 98.96% | Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. | ||||||||||||||||||||
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Tyrphostin A1 (Standard) | ≥98% | Tyrphostin A1 (Standard) is the analytical standard of Tyrphostin A1. This product is intended for research and analytical applications. Tyrphostin A1 (AG9) can inhibit CD40L-stimulated IL-12 production and antigen-induced Th1 cell production in macrophage culture. | ||||||||||||||||||||
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References
- Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114(1-2):69-79. [Content Brief]
- Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87(3):235-9. [Content Brief]
