2. Inhibitory Antibodies
  3. Bleselumab

Bleselumab  (Synonyms: ASKP 1240; Anti-Human CD40 Recombinant Antibody)

Cat. No.: HY-P99257 Purity: 98.97%
COA

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Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd:  0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection.

For research use only. We do not sell to patients.

Bleselumab Chemical Structure

Bleselumab Chemical Structure

CAS No. : 1453067-91-8

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Bleselumab Related Antibodies

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Description

Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd:  0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection[1].

IC50 & Target

CD40[1]
In Vitro

Bleselumab (0-1 μg/mL, 48 h) dose-depently inhibits PBMCs proliferation induced by soluble CD154[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bleselumab Related Antibodies

Cell Viability Assay[2]

Cell Line: PBMCs
Concentration: 0-1 μg/mL
Incubation Time: 48 h
Result: Inhibited PBMC proliferation induced by shCD154 in human, cynomolgus monkey and rabbit blood samples.
In Vivo

Bleselumab (0.1-10 mg/kg, i.v.) inhibits Delayed-type hypersensitivity (DTH) reaction in cynomolgus monkeys[2].
Bleselumab (2 mg/kg, i.v.) prolongs renal allograft survival in Cynomolgus monkeys[3].
Bleselumab (2 or 5 mg/kg, i.v.) together with Tacrolimus (HY-13756) shows a longer median survival time (MST) than monotherapy[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[2].
Dosage: 0.1, 1 and 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Inhibited anti-TTx IgG and anti-TTx IgM productions in a concentration-dependent manner.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Bleselumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.97%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bleselumab1453067-91-8ASKP 1240 Anti-Human CD40 Recombinant AntibodyASKP1240ASKP-1240OthersPBMCimmuneorgan transplanthypersensitivityrenal allograftInhibitorinhibitorinhibit

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