Search Result

Results for "

Cross-resistance

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) Antibiotic (4) Bacterial (8) Biochemical Assay Reagents (3) DNA/RNA Synthesis (3) Drug Derivative (1) Environmental Pollutants (2) Estrogen Receptor/ERR (1) Fungal (3) Glycosidase (1) HIV (1) Isotope-Labeled Compounds (1) Kinesin (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Parasite (6) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Reverse Transcriptase (1) Topoisomerase (1)
By Research Areas:	Cancer (4) Infection (19) Metabolic Disease (1)

By Targets:

Acetyl-CoA Carboxylase (2)

Antibiotic (4)

Bacterial (8)

Biochemical Assay Reagents (3)

DNA/RNA Synthesis (3)

Drug Derivative (1)

Environmental Pollutants (2)

Estrogen Receptor/ERR (1)

Fungal (3)

Glycosidase (1)

HIV (1)

Isotope-Labeled Compounds (1)

Kinesin (1)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

Parasite (6)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

Reverse Transcriptase (1)

Topoisomerase (1)

By Research Areas:

Cancer (4)

Infection (19)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133017

Amcenestrant 3 Publications Verification SAR439859	Estrogen Receptor/ERR	Cancer
SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC₅₀ of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER ⁺ breast cancer.

HY-173522

KIF2C-IN-1	Kinesin Microtubule/Tubulin	Cancer
KIF2C-IN-1 is a cell-penetrating, selective KIF2C inhibitor with fluorescent properties (E_x/E_m = 410/510 nm). KIF2C-IN-1 exhibits notable cytotoxicity and weak inhibitory effects on KIF2A/B. KIF2C-IN-1 prohibits the dissociation of KIF2C from microtubules. KIF2C-IN-1 inhibiting KIF2C reverses cross-resistance to microtubule-targeting agents. KIF2C-IN-1 reduces tumorigenesis in chemoresistant triple-negative breast cancer (TNBC) model in mice with the combination of Paclitaxel (HY-B0015) .

HY-B0826

Spirodiclofen BAJ-2740	Environmental Pollutants Parasite	Infection
Spirodiclofen (BAJ-2740) is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.

HY-122071

Bicyclomycin	Antibiotic Bacterial	Infection
Bicyclomycin is an antibiotic. Bicyclomycin exhibits selective antibacterial activity against Gram-negative bacteria such as Escherichia coli and Klebsiella spp., with no cross-resistance. Bicyclomycin is applicable to the research of infectious diseases .

HY-114591

Spiromesifen BSN 2060	Environmental Pollutants Drug Derivative Acetyl-CoA Carboxylase	Infection
Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase, and has no cross-resistance to any resistant mite or whitefly populations .

HY-N12109

Albizziin	Others	Others
Albizziin is an amino acid analog with activity as a competitive inhibitor of asparagine synthetase. Albizziin has been used to isolate Chinese hamster ovary cell mutants with altered levels of the target enzyme. Several mutational classes of albizziin can be distinguished based on cross-resistance to β-aspartic hydroxamic acid. Studies on asparagine synthetase have shown that resistance to albizziin may be associated with altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-145287

S-MGB-234	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .

HY-16745A

Lascufloxacin hydrochloride KRP-AM1977 hydrochloride	Bacterial	Infection
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

HY-178717

WML-01	Fungal	Infection
WML-01 is a fungicide with EC₅₀s of 0.079, 0.72 and 2.02 μg/mL against F. graminearum, F. fujikuroi and S. sclerotiorum. WML-01 disrupts the cell membrane of F. graminearum and induces deposition of lipid droplets. WML-01 inhibits Deoxynivalenol (DON) (HY-N6684) biosynthesis with no cross-resistance and strongly suppresses ribosomal subunit assembly, impairing protein synthesis. WML-01 effectively controls the fusarium head blight (FHB) epidemic .

HY-W414604

Dichloro(1,2-diaminocyclohexane)platinum(II)	Biochemical Assay Reagents	Cancer
Dichloro(1,2-diaminocyclohexane)platinum(II) is a platinum (II) analog and the oxaliplatin parent complex. Dichloro(1,2-diaminocyclohexane)platinum(II) is a potent chemotherapeutic with a wide spectrum of anticancer activity, low toxicity, and lack of cross resistance in many cisplatin-resistant cancers .

HY-W556802

5-Oxodecanoic acid	Biochemical Assay Reagents	Others
Dichloro(1,2-diaminocyclohexane)platinum(II) is a platinum (II) analog and the oxaliplatin parent complex. Dichloro(1,2-diaminocyclohexane)platinum(II) is a potent chemotherapeutic with a wide spectrum of anticancer activity, low toxicity, and lack of cross resistance in many cisplatin-resistant cancers .

HY-19869

VRX-480773	HIV Reverse Transcriptase	Infection
VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC₅₀ for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC₅₀s mostly < 1 nM. VRX-480773 can be used for research on AIDS .

HY-126742

MBX-1162	Bacterial	Others
MBX-1162 is a bisindole compound. In the study of its resistance mechanism in Staphylococcus aureus, it did not show cross-resistance with related compounds and was related to the substrate specificity of MepA and MepR.

HY-178064

Antiparasitic agent-29	Parasite Mitochondrial Metabolism	Infection
Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC₅₀ of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .

HY-114591S

Spiromesifen-d9	Isotope-Labeled Compounds	Others
Spiromesifen-d9 is a deuterated labeled Spiromesifen . Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid biosynthesis, and has no cross-resistance to any resistant mite or whitefly populations .

HY-114591R

Spiromesifen (Standard) BSN 2060 (Standard)	Acetyl-CoA Carboxylase Reference Standards	Infection
Spiromesifen (Standard) is the analytical standard of Spiromesifen. Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase, and has no cross-resistance to any resistant mite or whitefly populations .

HY-145287A

S-MGB-234 TFA	DNA/RNA Synthesis Parasite	Infection
S-MGB-234 TFA is a minor groove binder used for African Animal Trypanosomiasis (AAT). S-MGB-234 exhibits excellent in vitro activity against the primary pathogens of AAT: Trypanosoma congolense and Trypanosoma vivax. S-MGB-234 TFA does not show cross-resistance with current diamidine active molecules and is not internalized via the transporters used by diamidines .

HY-129262

Deoxypheganomycin D	Antibiotic Bacterial	Infection
Deoxypheganomycin D is a specific antimycobacterial inhibitor with no cross-resistance to other antibiotics such as Paromomycin (HY-B0956), Capreomycin (HY-P3270), Viomycin (HY-A0155), Streptothricin (HY-129065), Kanamycin (HY-16566), and Streptomycin (HY-B1906). Deoxypheganomycin D (28 μM) partially inhibits the growth of Mycobacterium 607, with no significant inhibitory effects on DNA, RNA, or protein synthesis. Deoxypheganomycin D (7 μM) affects leucine influx, not thymidine, and has the opposite effect on efflux. The effects of Deoxypheganomycin D may be related to cell membrane and specific mycobacterial lipid components.

HY-116781

PD 114595	Biochemical Assay Reagents	Others
PD 114595 is a Benzothiopyrano-indazole compound .

HY-B0826R

Spirodiclofen (Standard) BAJ-2740 (Standard)	Reference Standards Parasite	Infection
Spirodiclofen (BAJ-2740) (Standard) is the analytical standard of Spirodiclofen. This product is intended for research and analytical applications. Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.

HY-124408

Mepronil	Fungal	Infection
Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-179118

Antimalarial agent 53	Parasite	Infection
Antimalarial agent 53 (compound 31) is an antimalarial agent. Antimalarial agent 53 blocks protein synthesis by inhibiting the cytoplasmic ribosomes of malaria parasites, exhibiting potent antimalarial activity (IC₅₀ = 3.9 nM) and good selectivity. Antimalarial agent 53 has no cross resistance and good safety. Antimalarial agent 53 can be used for research on malaria .

HY-124408R

Mepronil (Standard)	Reference Standards Fungal	Infection
Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .

HY-146194

NHEJ inhibitor-1	Reactive Oxygen Species (ROS)	Cancer
NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction .

HY-124195

Antitubercular agent-57	Bacterial	Infection
Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis .

HY-W780694

PD 124816	Bacterial Antibiotic DNA/RNA Synthesis Topoisomerase	Infection
PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria .

HY-159796A

Cefetecol GR69153	Bacterial Antibiotic Glycosidase	Infection Metabolic Disease
Ceftezole (GR69153) is a broad-spectrum cephalosporin antibiotic and an α-glucosidase inhibitor. Ceftezole inhibits bacterial cell lysis by inhibiting cell wall synthesis and binding to penicillin-binding proteins (PBPs). Ceftezole exhibits in vivo anti-diabetic activity in diabetic mice. Ceftezole can be used in antibacterial and anti-diabetic research .

Cat. No.	Product Name	Target	Research Area