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Cat. No.: HY-124195

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Antitubercular agent-57

Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 461431-74-3
Formula: C₁₃H₁₆N₄O₃
Molecular Weight:276.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitubercular agent-57 Chemical Structure

CAS No.: 461431-74-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

In Vitro

Antitubercular agent-57 (compound 10) (0.03-1000 μM; 7-21 d) potently inhibits the growth of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium, with a MIC of 0.25 μM against drug-susceptible and multidrug-resistant Mycobacterium tuberculosis^[1].
Antitubercular agent-57 (0.488-500 μM; 24-120 h) exhibits no in vitro antifungal activity against the tested yeast and mold strains, with an MIC value >500 μM^[1].
Antitubercular agent-57 (0.488-500 μM; 24-48 h) exhibits extremely low in vitro antibacterial activity against the tested Gram-positive and Gram-negative strains, with MIC values ≥250 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HuH7 (human hepatocellular carcinoma), A431 (human epidermoid carcinoma), MDCK (Madin-Darby canine kidney), HepG2 (human hepatocellular carcinoma)
Concentration:

30 μM
Incubation Time:

48 h
Result:

Resulted in relative cell viability of 137% (HuH7) compared to vehicle-treated controls.
Resulted in relative cell viability of 90% (A431) compared to vehicle-treated controls.
Resulted in relative cell viability of 84% (MDCK) compared to vehicle-treated controls).
Resulted in relative cell viability of 145% (HepG2) compared to vehicle-treated controls.
Yielded a selectivity index (SI=IC₅₀(HepG2)/MIC(M.
tuberculosis)) of >120.

Chemical Information

CAS No. 461431-74-3
Molecular Weight 276.29
Formula C₁₃H₁₆N₄O₃
SMILES

CC(C)(C)C(C=C1)=CC=C1OC2=NC([N+]([O-])=O)=NN2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Karabanovich G, Němeček J, Valášková L, et al. S-substituted 3, 5-dinitrophenyl 1, 3, 4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents[J]. European Journal of Medicinal Chemistry, 2017, 126: 369-383.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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