2. Anti-infection
  3. Bacterial
  4. Antitubercular agent-57

Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis.

For research use only. We do not sell to patients.

Antitubercular agent-57

Antitubercular agent-57 Chemical Structure

CAS No. : 461431-74-3

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Antitubercular agent-57 Related Antibodies

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Description

Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis[1].

In Vitro

Antitubercular agent-57 (compound 10) (0.03-1000 μM; 7-21 d) potently inhibits the growth of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium, with a MIC of 0.25 μM against drug-susceptible and multidrug-resistant Mycobacterium tuberculosis[1].
Antitubercular agent-57 (0.488-500 μM; 24-120 h) exhibits no in vitro antifungal activity against the tested yeast and mold strains, with an MIC value >500 μM[1].
Antitubercular agent-57 (0.488-500 μM; 24-48 h) exhibits extremely low in vitro antibacterial activity against the tested Gram-positive and Gram-negative strains, with MIC values ≥250 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitubercular agent-57 Related Antibodies

Cell Viability Assay[1]

Cell Line: HuH7 (human hepatocellular carcinoma), A431 (human epidermoid carcinoma), MDCK (Madin-Darby canine kidney), HepG2 (human hepatocellular carcinoma)
Concentration: 30 μM
Incubation Time: 48 h
Result: Resulted in relative cell viability of 137% (HuH7) compared to vehicle-treated controls.
Resulted in relative cell viability of 90% (A431) compared to vehicle-treated controls.
Resulted in relative cell viability of 84% (MDCK) compared to vehicle-treated controls).
Resulted in relative cell viability of 145% (HepG2) compared to vehicle-treated controls.
Yielded a selectivity index (SI=IC50(HepG2)/MIC(M.
tuberculosis)) of >120.
Molecular Weight

276.29

Formula

C13H16N4O3
CAS No.
SMILES

CC(C)(C)C(C=C1)=CC=C1OC2=NC([N+]([O-])=O)=NN2C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitubercular agent-57 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitubercular agent-57461431-74-3Antitubercular agent57Antitubercular agent 57Bacterialgram-positive bacteriaextensively drug-resistant strainsMycobacterium tuberculosisfungal strainsHuH7HepG2multidrug-resistant tuberculosisgram-negative bacteriaM. aviumM. kansasiiInhibitorinhibitorinhibit

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