461431-74-3
Chemical Structure
Antitubercular agent-57
- CAS No.: 461431-74-3
- Formula:C13H16N4O3
- Molecular Weight:276.29
IUPAC Name: 5-(4-(tert-butyl)phenoxy)-1-methyl-3-nitro-1H-1,2,4-triazole
InChIKey: HJDFBULFYOIQIU-UHFFFAOYSA-N
SMILES: CC(C)(C)C(C=C1)=CC=C1OC2=NC([N+]([O-])=O)=NN2C
Biological Activity: Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis[1].
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Antitubercular agent-57 | Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis. | |||||||||||||||||||||
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Keywords
