2. Anti-infection
  3. Bacterial Antibiotic
  4. Bicyclomycin

Bicyclomycin is an antibiotic. Bicyclomycin exhibits selective antibacterial activity against Gram-negative bacteria such as Escherichia coli and Klebsiella spp., with no cross-resistance. Bicyclomycin is applicable to the research of infectious diseases.

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Bicyclomycin

Bicyclomycin Chemical Structure

CAS No. : 38129-37-2

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Bicyclomycin Related Antibodies

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Description

Bicyclomycin is an antibiotic. Bicyclomycin exhibits selective antibacterial activity against Gram-negative bacteria such as Escherichia coli and Klebsiella spp., with no cross-resistance. Bicyclomycin is applicable to the research of infectious diseases[1][2].

In Vitro

Bicyclomycin (6-25 μg/mL; 2 h) induces dose-dependent morphological changes (cell elongation, spheroplast formation) in actively growing cells of E. coli strain 15 THU and the highly sensitive E. coli strain ATCC 27166[1].
Bicyclomycin (25-100 μg/mL; 0-60 min) inhibits RNA and protein synthesis in proliferating E. coli 15 THU cells, but does not affect their DNA or lipid synthesis[1].
Bicyclomycin (100 μg/mL, over 0-45 min) exerts a stronger inhibitory effect on bound lipoprotein synthesis (inhibition rate of approximately 95%) than on free lipoprotein (inhibition rate of approximately 60%) and envelope protein synthesis (inhibition rate of approximately 50%) in histidine-starved E. coli 15 THU cells, with no effect on cytoplasmic protein synthesis[1].
Bicyclomycin exhibits selective moderate antibacterial activity against specific Gram-negative bacteria (Escherichia coli NIHJ JC-2, Klebsiella pneumoniae ST-101, Salmonella typhosa T-287, Shigella flexneri 1a-2 W-A), with an MIC of 25 mcg/mL; it shows only weak activity against Sarcina lutea PCI-100 (MIC 250 mcg/mL); and it has no activity against other tested Gram-positive bacteria, Gram-negative bacteria, mycobacteria, fungi, or yeasts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bicyclomycin Related Antibodies
In Vivo

The acute toxicity of Bicyclomycin via intravenous injection exceeds 2 g/kg, while its acute toxicity via subcutaneous, oral and intraperitoneal administration exceeds 4 g/kg in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

302.28

Formula

C12H18N2O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@](C)(O)[C@@H]([C@]12C(N[C@](C(N1)=O)(C(CCO2)=C)O)=O)O
Structure Classification
Initial Source

sterptomyces cinnamoneus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Bicyclomycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bicyclomycin38129-37-2BacterialAntibioticantibacterial agentEscherichia coliEscherichiaGram-negative bacteriaInhibitorinhibitorinhibit

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