2. Anti-infection
  3. HIV Reverse Transcriptase
  4. VRX-480773

VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS.

For research use only. We do not sell to patients.

VRX-480773

VRX-480773 Chemical Structure

CAS No. : 878670-89-4

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Description

VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS[1].

IC50 & Target[1]

HIV-1 (WT)

0.14 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
HeLa CC50
>= 3 μM
Compound: 24; VRX-480773
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by cellTiter-glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by cellTiter-glo assay
[PMID: 36708678]
MT4 CC50
5.821 μM
Compound: VRX-480773
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 4 days MTT method
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 4 days MTT method
[PMID: 26162497]
MT4 EC50
0.00014 μM
Compound: VRX-480773
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
[PMID: 26162497]
MT4 EC50
0.00023 μM
Compound: VRX-480773
Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
[PMID: 26162497]
MT4 EC50
0.14 μM
Compound: VRX-480733
Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
[PMID: 23084898]
MT4 EC50
0.14 μM
Compound: VRX-480773
Antiviral activity against HIV1 3B in human MT4 cells assessed as protection of cell against virus-induced cytopathogenicity
Antiviral activity against HIV1 3B in human MT4 cells assessed as protection of cell against virus-induced cytopathogenicity
[PMID: 18824350]
MT4 EC50
0.14 μM
Compound: VRX-480773
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
[PMID: 21872971]
MT4 EC50
0.14 μM
Compound: VRX-480773
Antiviral activity against HIV-1 3B infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
Antiviral activity against HIV-1 3B infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
[PMID: 22883027]
MT4 EC50
0.23 μM
Compound: VRX-480733
Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103N/Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103N/Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
[PMID: 23084898]
MT4 EC50
0.23 μM
Compound: VRX-480773
Antiviral activity against HIV-1 3B harboring RT K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
Antiviral activity against HIV-1 3B harboring RT K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
[PMID: 21872971]
MT4 EC50
0.23 μM
Compound: VRX-480773
Antiviral activity against HIV-1 RES056 harboring RT K103N/Y181C mutant gene infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
Antiviral activity against HIV-1 RES056 harboring RT K103N/Y181C mutant gene infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
[PMID: 22883027]
Molecular Weight

592.92

Formula

C23H19BrClN5O3S2
CAS No.
SMILES

O=C(NC1=CC=C(S(=O)(N)=O)C=C1Cl)CSC2=NN=C(Br)N2C3=C4C=CC=CC4=C(C5CC5)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VRX-480773 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VRX-480773878670-89-4VRX480773VRX 480773HIVReverse TranscriptaseHuman immunodeficiency virusNNRTIHIV-1drug resistancereverse transcriptase inhibitorcross-resistancepharmacokineticsantiviral activityInhibitorinhibitorinhibit

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