878670-89-4
Chemical Structure
VRX-480773
- CAS. Nr.: 878670-89-4
- Formula:C23H19BrClN5O3S2
- Molecular Weight:592.92
IUPAC Name: 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-chloro-4-sulfamoylphenyl)acetamide
InChIKey: JMAGRGYNUBAGRG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(S(=O)(N)=O)C=C1Cl)CSC2=NN=C(Br)N2C3=C4C=CC=CC4=C(C5CC5)C=C3
Biological Activity: VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS[1].
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VRX-480773 | VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS. | |||||||||||||||||||||
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Keywords
