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Drp1-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) Antibiotic (2) Apoptosis (2) ATP Synthase (1) DNA/RNA Synthesis (2) Dynamin (11) Isotope-Labeled Compounds (1) Mitophagy (2) PINK1/Parkin (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (9) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125222

*Drp1-IN-1*	Dynamin	Others
Drp1-IN-1 is a dynamin-1-like protein *(Drp1)* inhibitor with an IC₅₀ of 0.91 μM. Drp1 mediates the fission of the outer mitochondrial membrane. Drp1-IN-1 can be used to study diseases associated with mitochondrial dysfunction .

HY-N10470

Bleomycin A5 1 Publications Verification PINgyangmycIN	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy	Infection Cancer
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits *Drp1*-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

HY-P10368

P110 heptapeptide	Dynamin Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
P110 heptapeptide is a peptide inhibitor of the *Drp1-Fis1* interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of *Drp1*, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases .

HY-152086

DRP1i27	Dynamin	Cardiovascular Disease
DRP1i27 is a potent inhibitor of human *Drp1* (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-P2280

TAT-P110 P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 .

HY-152086A

DRP1i27 dihydrochloride	Dynamin	Cardiovascular Disease
DRP1i27 dihydrochloride is a potent inhibitor of human *Drp1* (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-P6374

IIQLPEIVVV TFA	Dynamin	Neurological Disease
IIQLPEIVVV TFA is a specific inhibitor of *Drp1-Mff* interaction. IIQLPEIVVV TFA can distinguish physiological from pathological fission and block physiological fission, thus leading to mitochondrial dysfunction. IIQLPEIVVV TFA can be used in the study of Huntington's disease .

HY-125918

Bleomycin A5 hydrochloride PINgyangmycIN hydrochloride	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy	Infection Cancer
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits *Drp1*-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

HY-155656

Anti-inflammatory agent 49	Dynamin	Inflammation/Immunology
nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of *Drp1-Fis1* interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC₅₀ of SC9 inhibiting GTPase in vitro is 270 nM .

HY-P11005

P259	Dynamin ATP Synthase	Neurological Disease
P259 is a *Drp1-Mff* inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model .

HY-13338

Mabuterol	Adrenergic Receptor	Cardiovascular Disease
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-W755295

Mabuterol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-152051S

Mabuterol-d9 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-W755295R

Mabuterol hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Mabuterol (hydrochloride) (Standard) is the analytical standard of Mabuterol (hydrochloride). This product is intended for research and analytical applications. Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-13338R

Mabuterol (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease
Mabuterol (Standard) is the analytical standard of Mabuterol. This product is intended for research and analytical applications. Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-176973

DRP1 Allosteric-IN-1	Dynamin	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
DRP1 Allosteric-IN-1 (Compound 1) is an allosteric inhibitor of *DRP1* with an IC₅₀ value for the *DRP1:MiD49* protein-protein interaction of 3.6 μM. DRP1 Allosteric-IN-1 can be used to study various diseases related to mitochondrial division disorders .

Cat. No.	Product Name	Target	Research Area

HY-P10368

P110 heptapeptide	Dynamin Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
P110 heptapeptide is a peptide inhibitor of the *Drp1-Fis1* interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of *Drp1*, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases .

HY-P2280

TAT-P110 P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 .

HY-P6374

IIQLPEIVVV TFA	Dynamin	Neurological Disease
IIQLPEIVVV TFA is a specific inhibitor of *Drp1-Mff* interaction. IIQLPEIVVV TFA can distinguish physiological from pathological fission and block physiological fission, thus leading to mitochondrial dysfunction. IIQLPEIVVV TFA can be used in the study of Huntington's disease .

HY-P11005

P259	Dynamin ATP Synthase	Neurological Disease
P259 is a *Drp1-Mff* inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10470

Bleomycin A5 1 Publications Verification PINgyangmycIN	Structural Classification Natural Products Microorganisms Animals Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits *Drp1*-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

HY-125918

Bleomycin A5 hydrochloride PINgyangmycIN hydrochloride	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits *Drp1*-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

Cat. No.	Product Name	Chemical Structure

HY-152051S

Mabuterol-d9 hydrochloride
Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

Mabuterol-d9 hydrochloride

Mabuterol-d₉ (hydrochloride) is deuterium labeled Mabuterol (hydrochloride). Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

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Drp1-IN-1

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products