Mabuterol

Cat. No.: HY-13338: FAQs
Data Sheet Handling Instructions

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Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB.

For research use only. We do not sell to patients.

Mabuterol Chemical Structure

CAS No. : 56341-08-3

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Other Forms of Mabuterol:

Mabuterol-d₉ Get quote
Mabuterol hydrochloride Get quote

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Purity & Documentation
References
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Description

IC₅₀ & Target^[1]^[2]

Beta-2 adrenergic receptor

In Vitro

Mabuterol (10-60 µM; 48 h) inhibits the proliferation of ASMCs induced by PDGF-BB^[2].
Mabuterol (50 µM; 1h) suppresses the increase of intracellular Ca2+ induced by PDGF-BB (25 ng/ml)^[2].
Mabuterol (50 µM; 48 h) significantly suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	rat ASMCs^[2]
Concentration:	10, 20, 30, 40, 50, 60 µM
Incubation Time:	24, 48 h
Result:	Inhibited the proliferation of ASMCs induced by PDGF-BB (25 ng/ml) in a dose-dependent maner at 48 h.

Molecular Weight

310.74

Formula

C₁₃H₁₈ClF₃N₂O

CAS No.

56341-08-3

SMILES

CC(NCC(O)C1=CC(C(F)(F)F)=C(N)C(Cl)=C1)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. [Content Brief]

[2]. Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72.

Mabuterol Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mabuterol56341-08-3Adrenergic ReceptorBeta ReceptorASMCsDrp-1cyclinD1PCNAPDGF-BBMfn-2Ca2+Inhibitorinhibitorinhibit

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