56341-08-3
56341-08-3
Chemical Structure
Mabuterol
- CAS No.: 56341-08-3
- Formula:C13H18ClF3N2O
- Molecular Weight:310.74
IUPAC Name: 1-(4-amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethanol
InChIKey: JSJCTEKTBOKRST-UHFFFAOYSA-N
SMILES: CC(NCC(O)C1=CC(C(F)(F)F)=C(N)C(Cl)=C1)(C)C
Biological Activity: Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].
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Mabuterol | 99.96% | Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB. | ||||||||||||||||||||
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Mabuterol (Standard) | ≥98% | Mabuterol (Standard) is the analytical standard of Mabuterol. This product is intended for research and analytical applications. Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB. | ||||||||||||||||||||
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Mabuterol-d9 | Mabuterol-d9 is a deuterium labeled Mabuterol. Mabuterol is an agonist of the β2-adrenergic receptor. | |||||||||||||||||||||
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References
- [1]. Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. [Content Brief]
- [2]. Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72.
