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Results for "

PDGF-BB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) ERK (2) PDGFR (3) Ras (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (4) Inflammation/Immunology (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0366

Sennoside B 1 Publications Verification	PDGFR	Cancer
Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .

HY-N2484

Methylnissolin Astrapterocarpan	PDGFR ERK	Cardiovascular Disease
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .

HY-13338

Mabuterol	Adrenergic Receptor	Cardiovascular Disease
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-W755295

Mabuterol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .

HY-N0366R

Sennoside B (Standard)	PDGFR	Cancer
Sennoside B (Standard) is the analytical standard of Sennoside B. This product is intended for research and analytical applications. Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .

HY-N0590

Corynoxeine 4 Publications Verification	ERK	Cardiovascular Disease
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.

HY-115376

Z62954982 ZINC08010136	Ras	Inflammation/Immunology
Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC₅₀=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC₅₀=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA) .

Sennoside B 1 Publications Verification	Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Plants Cassia angustifolia Disease Research Fields Cancer	PDGFR
Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .

Methylnissolin Astrapterocarpan	Cardiovascular Disease Monophenols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields	PDGFR ERK
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .

Corynoxeine 4 Publications Verification	Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Source classification Rubiaceae Plants Disease Research Fields Indole Alkaloids	ERK
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.

Sennoside B (Standard)	Quinones Structural Classification Classification of Application Fields Leguminosae Source classification Plants Cassia angustifolia Disease Research Fields Cancer	PDGFR
Sennoside B (Standard) is the analytical standard of Sennoside B. This product is intended for research and analytical applications. Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .

Recombinant Proteins Recommended:

PDGF-BB

Species:	Human (5) Rhesus Macaque (1) Mouse (3) Rat (2) Bovine (1) Cynomolgus (1) Canine (1)
Tag:	His (7) Tag Free (6) Fc (1)
Source:	HEK293 (1) P. pastoris (6) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P7055G

	*GMP PDGF-BB* Protein, Human** 2 Publications Verification PDGFBB; PDGF-BB	Human	E. coli
	The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. GMP PDGF-BB Protein, Human is the recombinant human-derived PDGF-BB protein, expressed by E. coli , with tag free. The total length of GMP PDGF-BB Protein, Human is 109 a.a., with molecular weight of ~14.0 kDa.

HY-P70699

	PDGF-BB Protein, Mouse (His) PDGFBB; PDGF-BB	Mouse	E. coli
	PDGF-BB protein is an important member of the PDGF/VEGF growth factor family and plays a vital role in cell signaling and tissue development, contributing to cell growth, angiogenesis and blood vessel development. Its membership emphasizes the importance of fundamental physiological processes that coordinate tissue homeostasis. PDGF-BB Protein, Mouse (His) is the recombinant mouse-derived PDGF-BB protein, expressed by E. coli , with C-6*His labeled tag. The total length of PDGF-BB Protein, Mouse (His) is 109 a.a., with molecular weight of ~15.0 kDa.

HY-P7055

	PDGF-BB Protein, Human Maximum Cited Publications 11 Publications Verification rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV	Human	E. coli
	PDGF-BB Protein, Human is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.

HY-P7087

	PDGF-BB Protein, Mouse 1 Publications Verification rMuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV	Mouse	E. coli
	PDGF-BB Protein, Mouse is an active PDGF isoform, used in cell culture applications.

HY-P7055B

	PDGF-BB Protein, Human (His) rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV	Human	E. coli
	The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. PDGF-BB Protein, Human (His) is the recombinant human-derived PDGF-BB protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDGF-BB Protein, Human (His) is 109 a.a., with molecular weight of approximately 15 kDa.

HY-P7055A

	PDGF-BB Protein, Human (P.pastoris) rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV	Human	P. pastoris
	PDGF-BB Protein, Human (P.pastoris) is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.

HY-P7278

	PDGF-BB Protein, Rat 2 Publications Verification rRtPDGF-BB; PDGF-2; PDGFb	Rat	E. coli
	PDGF-BB Protein, Rat is a member of PDGF family, which promotes cell proliferation, survival and migration, through binding to the tyrosine kinase PDGF receptor.

HY-P7278A

	PDGF-BB Protein, Rat (His) rRtPDGF-BB; PDGF-2; PDGFb	Rat	E. coli
	PDGF-BB Protein, Rat is a member of PDGF family, which promotes cell proliferation, survival and migration, through binding to the tyrosine kinase PDGF receptor.

HY-P701237

	PDGF-BB Protein, Bovine PDGFB; PDGFB protein; Platelet derived growth factor subunit B	Bovine	P. pastoris
	PDGF-BB protein is an important member of the PDGF/VEGF growth factor family and plays a vital role in cell signaling and tissue development, contributing to cell growth, angiogenesis and blood vessel development. Its membership emphasizes the importance of fundamental physiological processes that coordinate tissue homeostasis. PDGF-BB Protein, Bovine is the recombinant bovine-derived PDGF-BB protein, expressed by P. pastoris , with tag free. The total length of PDGF-BB Protein, Bovine is 109 a.a., with molecular weight of 10-18 kDa.

HY-P73351

	PDGF-BB Protein, Human (P.pastoris, His) Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS	Human	P. pastoris
	The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. PDGF-BB Protein, Human (P.pastoris, His) is the recombinant human-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Human (P.pastoris, His) is 109 a.a., with molecular weight of ~14.3 kDa.

HY-P73352

	PDGF-BB Protein, Mouse (P.pastoris, His) Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS	Mouse	P. pastoris
	PDGF-BB, a crucial growth factor, regulates diverse cellular processes, including development, proliferation, migration, survival, and chemotaxis. It is vital for tissue proliferation, blood vessel development, and kidney glomeruli formation. PDGF-BB interacts with PDGFRA, PDGFRB, XLKD1, LRP1, and SORL1, highlighting its versatile cellular involvement. PDGF-BB Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Mouse (P.pastoris, His) is 109 a.a., with molecular weight of ~14.2 kDa.

HY-P74642

	PDGF-BB Protein, Canine (P.pastoris, His) Platelet-derived growth factor subunit B; PDGF-2; PDGFB	Canine	P. pastoris
	PDGF-BB controls multiple cellular processes, including development, proliferation, migration, survival, and chemotaxis. It is essential for normal cell proliferation and recruitment, wound healing, vascular development, and glomerular formation in various tissues. PDGF-BB Protein, Canine (P.pastoris, His) is the recombinant canine-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Canine (P.pastoris, His) is 109 a.a., with molecular weight of ~14.9 kDa.

HY-P75966

	PDGF-BB Protein, Cynomolgus (HEK293, Fc) Platelet-derived growth factor subunit B; PDGF-2; PDGFB	Cynomolgus	HEK293
	PDGF-BB is a growth factor frequently overexpressed in cancers, are novel potent lymphangiogenic factors. PDGF-BB Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PDGF-BB protein, expressed by HEK293 , with N-mFc labeled tag. The total length of PDGF-BB Protein, Cynomolgus (HEK293, Fc) is 109 a.a., with molecular weight of ~43 & 32 kDa, respectively.

HY-P74641

	PDGF-BB Protein, Rhesus Macaque (P.pastoris, His) Platelet-derived growth factor subunit B; PDGF-2; PDGFB	Rhesus Macaque	P. pastoris
	PDGF-BB Protein is a member of the PDGF family and promotes cell proliferation, survival, and migration by binding to the tyrosine kinase PDGF receptor. PDGF-BB Protein promotes tendon healing and neuroregulation after spinal cord hemisection in primates. PDGF-BB Protein, Rhesus Macaque (P.pastoris, His) is the recombinant Rhesus Macaque-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Rhesus Macaque (P.pastoris, His) is 109 a.a., with molecular weight of ~14.2 kDa.


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PDGF-BB

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Natural
Products