1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    MAPK/ERK Pathway
  2. PDGFR
    ERK
  3. Methylnissolin

Methylnissolin (Synonyms: Astrapterocarpan)

Cat. No.: HY-N2484
Handling Instructions

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade.

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Methylnissolin Chemical Structure

Methylnissolin Chemical Structure

CAS No. : 73340-41-7

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Description

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].

IC50 & Target[1]

PDGFR

10 μM (IC50)

ERK1

 

ERK2

 

Molecular Weight

300.31

Formula

C₁₇H₁₆O₅

CAS No.

73340-41-7

SMILES

COC1=C2O[[email protected]]3([H])[[email protected]](COC4=CC(O)=CC=C34)([H])C2=CC=C1OC

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Methylnissolin
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