73340-41-7
Chemical Structure
Methylnissolin
Synonym(s): Astrapterocarpan
- CAS No.: 73340-41-7
- Formula:C17H16O5
- Molecular Weight:300.31
IUPAC Name: (6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-ol
InChIKey: UOVGCLXUTLXAEC-WFASDCNBSA-N
SMILES: COC1=C2O[C@]3([H])[C@](COC4=CC(O)=CC=C34)([H])C2=CC=C1OC
Biological Activity: Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc.[1][2][3][4]
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methylnissolin | 99.92% | Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc. | ||||||||||||||||||||
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- [1]. Wu J, et al. Methylnissolin mitigates microglia-mediated neuroinflammation and ischemic brain injury through PI3K/AKT and MAPK pathways. Eur J Pharmacol. 2026;1011:178431. [Content Brief]
- [2]. Feng Y, et al. Dual suppression of AKT/MAPK signaling and activation of Nrf2 by methylnissolin attenuates osteoclastogenesis and prevents postmenopausal osteoporosis. Int Immunopharmacol. 2026;169:115942. [Content Brief]
- [3]. Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005;525(1-3):41-47. [Content Brief]
- [4]. Choi YJ, et al. Protective effects of methylnissolin and methylnissolin-3-O-β-d-glucopyranoside on TNF-α-induced inflammation in human dermal fibroblasts. Toxicol In Vitro. 2025;104:106005. [Content Brief]
Keywords
