(+)-Medicarpin
(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action.
For research use only. We do not sell to patients.
- CAS No.: 33983-39-0
- Formula: C16H14O4
- Molecular Weight:270.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
ERβ |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
39.5 μM
Compound: 32
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
| B16-BL6 | IC50 |
42.4 μM
Compound: 32
|
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
| HeLa | IC50 |
23.4 μM
Compound: 32
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
| HT-1080 | IC50 |
28.4 μM
Compound: 32
|
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
| KB | EC50 |
2.4 μg/mL
Compound: 2
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 11720542] |
| Lewis lung carcinoma cell line | IC50 |
17.2 μM
Compound: 32
|
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
Chemical Information
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CAS No. 33983-39-0
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Molecular Weight 270.28
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Formula C16H14O4
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SMILES
OC1=CC=C([C@]2([H])[C@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)