(Rac)-Medicarpin
(Rac)-Medicarpin (3-Hydroxy-9-methoxypterocarpan) is a pterocarpan isoflavonoid phytoalexin with antimicrobial activity and anti-tumor promoting activity. (Rac)-Medicarpin induces apoptosis in human peripheral blood mononuclear cells. (Rac)-Medicarpin is also a defensive secondary metabolite produced in sword bean calli in response to exposure to spore suspensions of the non-pathogenic fungus Pithomyces chartarum or HgCl2.
For research use only. We do not sell to patients.
- CAS No.: 607363-34-8
- Formula: C16H14O4
- Molecular Weight:270.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Rac)-Medicarpin (72 h) exhibits no cytotoxicity against human epidermoid carcinoma cells (KB) and breast cancer cells (BC), with an IC50 > 100 μM for both cell lines[1].
(Rac)-Medicarpin (5 days) exhibits no cytotoxic activity against human small cell lung cancer (NCI-H 187) cells, with an IC50 > 100 μM[1].
(Rac)-Medicarpin is a product generated from calli of Canavalia gladiata after treatment with Pithomyces chartarum spores, and its accumulation is upregulated synchronously with phenylalanine ammonia-lyase (PAL) and isoflavone-specific O-methyltransferase (OMT)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 607363-34-8
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Appearance Solid
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Molecular Weight 270.28
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Formula C16H14O4
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SMILES
OC1=CC=C2C(OC3=CC(OC)=CC=C34)C4COC2=C1
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Synonyms
3-Hydroxy-9-methoxypterocarpan
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ngamrojanavanich N, et al. Cytotoxic constituents from Butea superba Roxb. Journal of ethnopharmacology. 2007 Jan 19;109(2):354-8. [Content Brief]
[2].
Gustine DL, Sherwood RT. Regulation of Phytoalexin Synthesis in Jackbean Callus Cultures: Stimulation of Phenylalanine Ammonia-Lyase and o-Methyltransferase. Plant Physiol. 1978 Feb;61(2):226-30.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Medicarpin Related Classifications
HY-N6052A Related Classifications
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- (Rac)-Medicarpin
- 607363-34-8
- 3-Hydroxy-9-methoxypterocarpan
- Apoptosis
- alfalfa
- Butea superba Roxb.
- human peripheral blood mononuclear cells
- human epidermoid carcinoma cell lines
- Pithomyces chartarum
- pterocarpan isoflavonoid phytoalexin
- breast cancer cell lines
- jackbean callus tissues
- small cell lung carcinoma cell lines
- red clover
- Inhibitor
- inhibitor
- inhibit