Cytotoxic constituents from Butea superba Roxb

  • J Ethnopharmacol. 2007 Jan 19;109(2):354-8. doi: 10.1016/j.jep.2006.07.034.
Nattaya Ngamrojanavanich  1 ,  Aimon Loontaisong ,  Somchai Pengpreecha ,  Wichai Cherdshewasart ,  Surachai Pornpakakul ,  Khanitha Pudhom ,  Sophon Roengsumran ,  Amorn Petsom
Affiliations
  • 1. Research Centre for Bioorganic Chemistry, Faculty of Science, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok, Thailand. [email protected]
PMID: 16973318 DOI: 10.1016/j.jep.2006.07.034
Abstract

A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four Isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) (microM) values of 37.3+/-2.5 and 71.1+/-0.8 and on BC cell lines with IC(50) (microM) values of 32.7+/-1.5 and 47.3+/-0.3, respectively.

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