Total Synthesis of (+)-Medicarpin

  • J Nat Prod. 2017 Dec 22;80(12):3284-3288. doi: 10.1021/acs.jnatprod.7b00741.
Xiaoming Yang  1 ,  Yu Zhao  1 ,  Min-Tsang Hsieh  1  2  3 ,  Guang Xin  1 ,  Rong-Tsun Wu  4 ,  Pei-Lun Hsu  4 ,  Lin-Yea Horng  4 ,  Hui-Ching Sung  4 ,  Chien-Hsin Cheng  5 ,  Kuo-Hsiung Lee  1  2
Affiliations
  • 1. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  • 2. Chinese Medicine Research and Development Center, China Medical University and Hospital , Taichung 40402, Taiwan.
  • 3. School of Pharmacy, China Medical University , Taichung 404, Taiwan.
  • 4. Research Center for Drug Discovery, National Yang-Ming University , Taipei 112, Taiwan.
  • 5. PhytoHealth Corporation, Maywafa Biopharma Group, Taipei 105, Taiwan.
PMID: 29164880 DOI: 10.1021/acs.jnatprod.7b00741
Abstract

(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral Oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases.

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