Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

  • J Nat Prod. 2001 Nov;64(11):1483-5. doi: 10.1021/np0103158.
E K Seo  1 ,  N C Kim ,  Q Mi ,  H Chai ,  M E Wall ,  M C Wani ,  H A Navarro ,  J P Burgess ,  J G Graham ,  F Cabieses ,  G T Tan ,  N R Farnsworth ,  J M Pezzuto ,  A D Kinghorn
Affiliations
  • 1. Chemistry and Life Sciences, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709, USA.
PMID: 11720542 DOI: 10.1021/np0103158
Abstract

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.