Homopterocarpin
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Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective, antioxidant and antiplasmodial activity. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.
For research use only. We do not sell to patients.
- CAS No.: 606-91-7
- Formula: C17H16O4
- Molecular Weight:284.31
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
5.2 μg/mL
Compound: 3, homopterocarpin
|
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| CCRF-CEM | IC50 |
5.5 μg/mL
Compound: 3, homopterocarpin
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Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
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[PMID: 15787450] |
| HCT-8 | IC50 |
6.4 μg/mL
Compound: 3, homopterocarpin
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Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
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[PMID: 15787450] |
| HL-60 | IC50 |
3.9 μg/mL
Compound: 3, homopterocarpin
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| MCF7 | IC50 |
18.5 μg/mL
Compound: 3, homopterocarpin
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Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 15787450] |
| U-937 | IC50 |
>100 μM
Compound: 18, homopterocarpin
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Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
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[PMID: 17158054] |
| U-937 | IC50 |
>100 μM
Compound: 18, homopterocarpin
|
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
|
[PMID: 17158054] |
| U-937 | IC50 |
>100 μM
Compound: 18, homopterocarpin
|
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
|
[PMID: 17158054] |
Chemical Information
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CAS No. 606-91-7
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Appearance Solid
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Molecular Weight 284.31
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Formula C17H16O4
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SMILES
COC1=CC=C([C@@]2([H])[C@@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
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Synonyms
(-)-Homopterocarpin; 3,9-Dimethoxypterocarpan
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
References
[1]. Akinmoladun AC, et al. Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity. J Basic Clin Physiol Pharmacol. 2015 Nov;26(6):555-62. [Content Brief]
[2]. Oh JM, et al. Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B. Molecules. 2022 Dec 28;28(1):258. [Content Brief]
[3]. Alsaleem MA, et al. Homopterocarpin alleviates methoxychlor-induced hepatotoxicity via modulating thioredoxin/peroxiredoxin and TLR4/MyD88 pathway: A comprehensive biochemical, histopathological, and computational analysis. Tissue Cell. 2026;98:103174. [Content Brief]
[4]. Wahyuni DK, et al. In silico anti-SARS-CoV-2, antiplasmodial, antioxidant, and antimicrobial activities of crude extracts and homopterocarpin from heartwood of Pterocarpus macrocarpus Kurz. Heliyon. 2023;9(2):e13644. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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