Cytotoxic flavonoids from Platymiscium floribundum

  • J Nat Prod. 2005 Mar;68(3):423-6. doi: 10.1021/np049854d.
Maria José C Falcão  1 ,  Yvone Brígido M Pouliquem ,  Mary Anne S Lima ,  Nilce Viana Gramosa ,  Letícia V Costa-Lotufo ,  Gardênia Carmen G Militão ,  Cláudia Pessoa ,  Manoel Odorico de Moraes ,  Edilberto R Silveira
Affiliations
  • 1. Curso de Pós-Graduação em Química Orgânica, Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12200, Fortaleza-Ce, 60021-940, Brazil.
PMID: 15787450 DOI: 10.1021/np049854d
Abstract

Two new isoflavonoids, 7-hydroxy-6,4'-dimethoxy-isoflavonequinone (1) and 2'-hydroxy-6,4',6' ',4' ''-tetramethoxy-[7-O-7' ']-bisisoflavone (2), and seven Other known Flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2',4,4'-trihydroxychalcone (isoliquiritigenin), and 7,4'-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3-6 showed cytotoxic activity when evaluated against five human Cancer cell lines in vitro.