1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

Corynoxeine 

Cat. No.: HY-N0590 Purity: 99.91%
Data Sheet SDS Handling Instructions

Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation; a useful and prospective compound in the prevention and treatment for vascular diseases.

For research use only. We do not sell to patients.
Corynoxeine Chemical Structure

Corynoxeine Chemical Structure

CAS No. : 630-94-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $138 In-stock
5 mg $125 In-stock
10 mg $225 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation; a useful and prospective compound in the prevention and treatment for vascular diseases. IC50 value: Target: ERK1/2 inhibitor; Natural compound in vitro: Pre-treatment of VSMCs with corynoxeine (5-50 microM) for 24 h resulted in significant decreases in cell number without any cytotoxicity; the inhibition percentages were 25.0+/-12.5, 63.0+/-27.5 and 88.0+/-12.5% at 5, 20 and 50 microM, respectively. Also, corynoxeine significantly inhibited the 50 ng/ml PDGF-BB-induced DNA synthesis of VSMCs in a concentration-dependent manner without any cytotoxicity; the inhibitions were 32.8+/-11.0, 51.8+/-8.0 and 76.9+/-7.4% at concentrations of 5, 20 and 50 microM, respectively [1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6147 mL 13.0736 mL 26.1472 mL
5 mM 0.5229 mL 2.6147 mL 5.2294 mL
10 mM 0.2615 mL 1.3074 mL 2.6147 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

382.45

Formula

C₂₂H₂₆N₂O₄

CAS No.

630-94-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 3.8 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.91%

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Product Name:
Corynoxeine
Cat. No.:
HY-N0590
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