1. Protein Tyrosine Kinase/RTK
  2. PDGFR
  3. Sennoside B

Sennoside B 

Cat. No.: HY-N0366 Purity: 99.44%
Handling Instructions

Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia). Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway.

For research use only. We do not sell to patients.

Sennoside B Chemical Structure

Sennoside B Chemical Structure

CAS No. : 128-57-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 76 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2].

Molecular Weight

862.74

Formula

C₄₂H₃₈O₂₀

CAS No.

128-57-4

SMILES

O[[email protected]@H]1[[email protected]@H](O)[[email protected]](OC2=C(C(C(C(O)=CC(C(O)=O)=C3)=C3[[email protected]]4([[email protected]@]5(C(C=CC=C6O[[email protected]]7[[email protected]](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](CO)O7)=C6C(C8=C5C=C(C(O)=O)C=C8O)=O)[H])[H])=O)C4=CC=C2)O[[email protected]](CO)[[email protected]]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (144.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1591 mL 5.7955 mL 11.5910 mL
5 mM 0.2318 mL 1.1591 mL 2.3182 mL
10 mM 0.1159 mL 0.5795 mL 1.1591 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (2.70 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.33 mg/mL (2.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Sennoside BPDGFRPlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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Product name:
Sennoside B
Cat. No.:
HY-N0366
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