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Results for "

EPHB4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bcr-Abl (1) c-Met/HGFR (1) DNA-PK (1) EGFR (2) Ephrin Receptor (6) mTOR (1) PDGFR (3) PI3K (1) Prostaglandin Receptor (1) PROTACs (2) Small Interfering RNA (siRNA) (1) Src (1) VEGFR (5)
By Research Areas:	Cancer (9) Cardiovascular Disease (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13258A

NVP-BHG712 4 Publications Verification BHG712	Ephrin Receptor	Cancer
NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC₅₀ values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively .

HY-136895

AZ12672857	Prostaglandin Receptor	Cancer
AZ12672857 is an orally active inhibitor of *EphB4* (IC₅₀=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC₅₀=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC₅₀=9 nM) .

HY-RS04436

EPHB4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EPHB4 Human Pre-designed siRNA Set A contains three designed siRNAs for EPHB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EPHB4 Human Pre-designed siRNA Set A EPHB4 Human Pre-designed siRNA Set A

HY-155684

SA-PA	PROTACs VEGFR PDGFR Ephrin Receptor	Cancer
SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and *EphB4* proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .

HY-155685

SA-VA	PROTACs VEGFR Ephrin Receptor Apoptosis	Cancer
SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and *EphB4* proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .

HY-16265

JI-101

Ephrin Receptor PDGFR VEGFR Cardiovascular Disease Cancer

JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ and EphB4 with potent anti-cancer activity.
HY-13258

NVP-BHG712 isomer

1 Publications Verification

Ephrin Receptor Cancer

NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4 .

JI-101	Ephrin Receptor PDGFR VEGFR	Cardiovascular Disease Cancer
JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ and *EphB4* with potent anti-cancer activity.

NVP-BHG712 isomer 1 Publications Verification	Ephrin Receptor	Cancer
NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4 .

HY-13314

Tesevatinib 4 Publications Verification XL-647; EXEL-7647; KD-019	EGFR VEGFR Ephrin Receptor	Cancer
Tesevatinib (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, *Flt4* and *EphB4* kinase with IC₅₀s of 0.3, 16, 1.5, 8.7, and 1.4 nM.

HY-N3634

Corylifol C	Others	Cancer
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

HY-15268

PP487	c-Met/HGFR PI3K DNA-PK mTOR Bcr-Abl Src VEGFR EGFR PDGFR	Cancer
PP487 is a dual inhibitor of tyrosine kinase/PI(3)Ks with IC₅₀ values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, *EphB4, and PDGFR*, respectively. PP487 can be used for cancer research .

Corylifol C	Structural Classification Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	Others
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

Recombinant Proteins Recommended:

EphB4

Species:	Human (5) Mouse (2)
Tag:	His (4) Tag Free (1) GST (1) Fc (2)
Source:	HEK293 (6) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77646

	EphB4 Protein, Human (HEK293, His) EPHB4; HTK; MYK1; TYRO11	Human	HEK293
	EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293, His) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB4 Protein, Human (HEK293, His) is 524 a.a., with molecular weight of 60-70 kDa.

HY-P73005

	EphB4 Protein, Mouse (HEK293, His) Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11	Mouse	HEK293
	Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB4 Protein, Mouse (HEK293, His) is 524 a.a., with molecular weight of ~75 kDa.

HY-P73002

	EphB4 Protein, Human (HEK293) Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11	Human	HEK293
	EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with tag free. The total length of EphB4 Protein, Human (HEK293) is 539 a.a., with molecular weight of 65-70 kDa.

HY-P73004

	EphB4 Protein, Mouse (HEK293, Fc) Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11	Mouse	HEK293
	Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB4 Protein, Mouse (HEK293, Fc) is 539 a.a., with molecular weight of ~110 kDa.

HY-P74171

	EphB4 Protein, Human (HEK293, Fc) Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11	Human	HEK293
	EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB4 Protein, Human (HEK293, Fc) is 539 a.a., with molecular weight of 105-115 kDa.

HY-P73003

	EphB4 Protein, Human (sf9, His-GST) Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11	Human	Sf9 insect cells
	EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (sf9, His-GST) is the recombinant human-derived EphB4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphB4 Protein, Human (sf9, His-GST) is 425 a.a., with molecular weight of ~66 kDa.

HY-P77545

	EphB4 Protein, Human (Biotinylated, HEK293, His) Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11	Human	HEK293
	EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB4 Protein, Human (Biotinylated, HEK293, His) is 539 a.a., with molecular weight of ~58.5 KDa.


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