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Enoyl-ACP reductase (InhA)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (8)
By Research Areas:	Infection (8)

Targets Recommended: Quinone Reductase 5 alpha Reductase Carbonyl Reductase Glutathione Reductase (GR) Aldose Reductase TrxR Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) GSNOR VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150588

InhA-IN-3	Bacterial	Infection
InhA-IN-3 (Compound TU12) is a Mycobacterium tuberculosis *InhA* (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 17.7 μM .

HY-150589

InhA-IN-4	Bacterial	Infection
InhA-IN-4 (TU14) is a Mycobacterium tuberculosis *InhA* (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 15.6 μM .

HY-147047

InhA-IN-2	Bacterial	Infection
InhA-IN-2 (Compound 23) is a Mycobacterium tuberculosis *InhA* (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 0.31 μM .

HY-168946

InhA-IN-9	Bacterial	Infection
InhA-IN-9 (compound 7h) is a Mycobacterium tuberculosis **InhA (an enoyl ACP-reductase)** inhibitor. InhA-IN-9 could bind to InhA. InhA-IN-9 shows a antituberculosis activity at MIC value of 2 μg/mL .

HY-169104

InhA-IN-8	Bacterial	Infection
InhA-IN-8 (compound 6c) is an orally active inhibitor of Mycobacterium tuberculosis *InhA* (enoyl ACP reductase). InhA-IN-8 has good inhibitory activity against Mtb UalRv (MIC = 0.5-1 μg/mL). InhA-IN-8 can be used in research on acute tuberculosis model mice .

HY-181866

Antibacterial agent 328	Bacterial	Infection
Antibacterial agent 328 is a **enoyl-ACP reductase (InhA)** inhibitor and antimycobacterial agent. Antibacterial agent 328 blocks mycolic acid biosynthesis in Mycobacterium tuberculosis. Antibacterial agent 328 acts on both drug-resistant and drug-susceptible Mycobacterium tuberculosis strains. Antibacterial agent 328 exhibits favorable pharmacokinetic properties, drug-likeness, and a safety-related selectivity index. Antibacterial agent 328 can be used for research on tuberculosis .

HY-181419

Antimycobacterial agent-16	Bacterial	Infection
Antimycobacterial agent-16 is a pyrazinamide derivative and antimycobacterial agent with a selectivity index >25 against HepG2 cells.Antimycobacterial agent-16 does not undergo hydrolysis by mycobacterial pyrazinamidase.Antimycobacterial agent-16 exerts activity against Mycobacterium tuberculosis H37Rv, multidrug-resistant Mycobacterium tuberculosis strains, and Mycobacterium kansasii.Antimycobacterial agent-16 shows no inhibitory activity against mycobacterial enoyl-ACP reductase (InhA).Antimycobacterial agent-16 has low cytotoxicity against HepG2 cells.Antimycobacterial agent-16 can be used for the research of tuberculosis .

HY-181779

Pyridomycin-4-F	Bacterial	Infection
Pyridomycin-4-F, Pyridomycin (HY-111402) derivative, is an antimycobacterial agent targeting fatty acid synthesis enzyme *InhA* (enoyl ACP reductase). Pyridomycin-4-F binds to the pyridomycin binding pocket of InhA, forms hydrogen bond interactions with Lys-165. Pyridomycin-4-F can be used for the research of tuberculosis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Enoyl-ACP reductase (InhA)

Inhibitors & Agonists