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Results for "

GABA-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Beta-secretase (1) Chloride Channel (1) Cholinesterase (ChE) (1) Drug Metabolite (1) Fluorescent Dye (1) GABA Receptor (25) Isotope-Labeled Compounds (2) Parasite (2) Reference Standards (5)
By Research Areas:	Cancer (1) Infection (3) Inflammation/Immunology (2) Neurological Disease (21)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15399

Vigabatrin 5+ Cited Publications γ-VINyl-GABA	GABA Receptor	Neurological Disease
Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by *GABA transaminase* .

HY-139584

Temgicoluril Tetramethylglycoluril	GABA Receptor	Neurological Disease Inflammation/Immunology
Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission .

HY-17599

Piperazine citrate 1 Publications Verification 1,4-Diazacyclohexane citrate	GABA Receptor Parasite	Infection
Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid *(GABA)* agonist . Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities .

HY-B0033

Vigabatrin hydrochloride 5+ Cited Publications γ-VINyl-GABA hydrochloride	GABA Receptor	Neurological Disease
Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by *GABA transaminase* .

HY-124030

3-Hydroxyphenazepam	Drug Metabolite	Neurological Disease
3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [ ³H]GABA uptake .

HY-103506

NNC-711 NO-711 hydrochloride	GABA Receptor	Neurological Disease
NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1) with IC₅₀ values of 0.04, 0.38, 171, 1700, 349, 622 μM for human GAT-1, rat GAT-1, rGAT-2, hGAT-3, rGAT-3, hBGT-3, respectively. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity ^[1] .

HY-W015050

1-Anthramine 1-AmINoanthracene	GABA Receptor Chloride Channel Fluorescent Dye	Neurological Disease
1-Anthramine (1-aminoanthracene) is a fluorescent general anesthetic. potentiates GABAergic transmission with K_d = 0.1 mM, for binding to the general anesthetic site in horse spleen apoferritin (HSAF). 1-Anthramine fluorescence is enhanced when bound to HSAF. 1-Anthramine potentiates chloride currents elicited by GABA. 1-Anthramine can reversibly inhibit the movement of Xenopus laevis, with an EC₅₀ value of 16 μM ^[1].

HY-149399

*GABA-IN-1*	GABA Receptor	Infection
GABA-IN-1 (Compound 6) is a *GABA* inhibitor. GABA-IN-1 has larvicidal activity and insecticidal effect, with mortality rates of 93% at 50 mg/L ^[1].

HY-W103105

R 29676	GABA Receptor	Neurological Disease
R 29676 is a neuroleptic agent and inhibits sodium-dependent GABA binding (GABA uptake) .

HY-N3478

Isohyenanchin HydroxycoriatIN	GABA Receptor	Neurological Disease
Isohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. Isohyenanchin also is a weak antagonist of ionotropic GABA receptors .

HY-W749797

Nitrazolam	GABA Receptor	Neurological Disease
Nitrazolam is a benzodiazepine compound, that may exhibit CNS depressant properties as traditional benzodiazepines, including sedation, hypnosis, anxiolysis, and anticonvulsant effects, by acting on GABA receptors .

HY-B0033S

Vigabatrin-13C,d2 hydrochloride γ-VINyl-GABA-13C,d2 hydrochloride	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-155238

E2730	GABA Receptor	Neurological Disease
E2730 is a noncompetitive but selective inhibitor of gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with orally available and antiepileptic activity. E2730-mediated GAT1 inhibition is positively correlated with environmental GABA levels and selectively inhibits GAT1-mediated GABA uptake. E2730 (5-50 mg/kg; po) in rat amygdala ignition model, and in mouse cornea ignition (5-50 mg/kg), drug resistance 6Hz-44mA has demonstrated in vivo efficacy in models of psychomotor epilepsy (5-50 mg/kg), fragile X syndrome (2.5-300 mg/kg), and Dravet syndrome (10 mg/kg, 20 mg/kg) ^[1].

HY-106875

Saripidem	GABA Receptor	Neurological Disease
Saripidem is a non-selective ligand for ω modulatory sites of GABA receptor .

HY-W103105R

R 29676 (Standard)	Reference Standards GABA Receptor	Neurological Disease
R 29676 is a neuroleptic agent and inhibits sodium-dependent GABA binding (GABA uptake) .

HY-117256

Gabazine free base SR95531 free base	GABA Receptor	Inflammation/Immunology
Gabazine is a selective and competitive antagonist of GABA_A receptor, with an IC₅₀ of 0.2 μM for GABA receptor .

HY-17599R

Piperazine citrate (Standard) 1,4-Diazacyclohexane citrate (Standard)	GABA Receptor Parasite Reference Standards	Infection
Piperazine (citrate) (Standard) is the analytical standard of Piperazine (citrate). This product is intended for research and analytical applications. Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist . Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities .

HY-155305

BuChE-IN-9	Cholinesterase (ChE) Beta-secretase GABA Receptor	Neurological Disease
BuChE-IN-9 (compound 22a) is a potent equine serum-derived BuChE (eqBuChE) inhibitor with an IC₅₀ of 173 nM. BuChE-IN-9 also inhibits human BACE1, Aβ aggregation, mouse GABA transporter 1 (mGAT1) and mGAT4. BuChE-IN-9 has significant antiamnesic properties ^[1].

HY-15399R

Vigabatrin (Standard) γ-VINyl-GABA (Standard)	Reference Standards GABA Receptor	Neurological Disease
Vigabatrin (Standard) is the analytical standard of Vigabatrin. This product is intended for research and analytical applications. Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-118207

LU-32-176B	GABA Receptor	Cancer
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and *mGAT1* with the IC₅₀ values of 2μM, 1μM, 4μM, respectively ^[1] .

HY-W778008

Rac-Vigabatrin-13C,d2 (Major)	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Rac-Vigabatrin- ¹³C,d₂ (Major) is the deuterium and ¹³C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-129090

CGS-9895	GABA Receptor	Neurological Disease
CGS-9895 is a *GABA* antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors .

HY-B0033R

Vigabatrin hydrochloride (Standard) γ-VINyl-GABA hydrochloride (Standard)	GABA Receptor Reference Standards	Neurological Disease
Vigabatrin (hydrochloride) (Standard) is the analytical standard of Vigabatrin (hydrochloride). This product is intended for research and analytical applications. Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-181135

Bicyclo-GABA	GABA Receptor	Neurological Disease
Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC₅₀ of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α₁β₂γ₂ GABA_A receptors with an EC₅₀ of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery ^[1].

HY-182944

GATT-44	GABA Receptor	Neurological Disease
GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC₅₀ of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated ¹⁸F-radiofluorination. The radiolabeled GATT-44 ([ ¹⁸F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases ^[1].

HY-103506R

NNC-711 (Standard) NO-711 hydrochloride (Standard)	Reference Standards GABA Receptor	Neurological Disease
NNC-711 (Standard) is the analytical standard of NNC-711 (HY-103506). This product is intended for research and analytical applications. NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1) with IC₅₀ values of 0.04, 0.38, 171, 1700, 349, 622 μM for human GAT-1, rat GAT-1, rGAT-2, hGAT-3, rGAT-3, hBGT-3, respectively. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3478

Isohyenanchin HydroxycoriatIN	Terpenoids Sesquiterpenes Campanulaceae Campanula medium L. Plants Source Classification	GABA Receptor
Isohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. Isohyenanchin also is a weak antagonist of ionotropic GABA receptors .

Cat. No.	Product Name	Chemical Structure

HY-B0033S

Vigabatrin-13C,d2 hydrochloride
Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

Vigabatrin-13C,d2 hydrochloride

Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-W778008

Rac-Vigabatrin-13C,d2 (Major)
Rac-Vigabatrin- ¹³C,d₂ (Major) is the deuterium and ¹³C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

Rac-Vigabatrin-13C,d2 (Major)

Rac-Vigabatrin- ¹³C,d₂ (Major) is the deuterium and ¹³C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

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