1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. LU-32-176B

LU-32-176B 

Cat. No.: HY-118207
Handling Instructions

LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively.

For research use only. We do not sell to patients.

LU-32-176B Chemical Structure

LU-32-176B Chemical Structure

CAS No. : 770688-66-9

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Description

LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].

IC50 & Target

LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].

In Vivo

LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

398.45

Formula

C₂₃H₂₄F₂N₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
LU-32-176B
Cat. No.:
HY-118207
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