770688-66-9
770688-66-9
Chemical Structure
LU-32-176B
- CAS No.: 770688-66-9
- Formula:C23H24F2N2O2
- Molecular Weight:398.45
IUPAC Name: 4-((4,4-bis(4-fluorophenyl)butyl)amino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol
InChIKey: QOSIKKDOOCQXMT-UHFFFAOYSA-N
SMILES: OC1=NOC2=C1C(CCC2)NCCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Biological Activity: LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].
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LU-32-176B | LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively. | |||||||||||||||||||||
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References
- [1]. Schousboe A, et al. GABA transporters as drug targets for modulation of GABAergic activity. Biochem Pharmacol. 2004;68(8):1557-1563. [Content Brief]
- [2]. White HS, et al. First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther. 2005;312(2):86 [Content Brief]
