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Gabazine free base

(Synonyms: SR95531 free base)
15 Cited Publications
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Based on 15 publication(s) in Google Scholar

Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of 0.2 μM for GABA receptor.

For research use only. We do not sell to patients.

  • CAS No.: 105538-73-6
  • Formula: C15H17N3O3
  • Molecular Weight:287.31
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Gabazine free base Chemical Structure
    Gabazine free base Chemical Structure
  • Experimental Validation Results for Gabazine free base
  • Experimental Validation Results for Gabazine free base
  • Experimental Validation Results for Gabazine free base
  • Experimental Validation Results for Gabazine free base
CAS No.: 105538-73-6
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Publications Citing Use of MedChemExpress (MCE) Gabazine free base

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Bio/Physico-chemical AssayIn Vivo Efficacy Study
  • Bio/Physico-chemical Assay
  • In Vivo Efficacy Study
  • Bio/Physico-chemical Assay
  • In Vivo Efficacy Study
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  • Gabazine free base Chemical Structure
    Gabazine free base Chemical Structure
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    Gabazine free base purchased from MedChemExpress. Usage Cited in: Nature. 2025 Oct;646(8087):1243-1253. [Abstract]

    Customer Validation
     A small fraction of the currents remained in two cells, after d-AP5 exposure, presented a shape consistent with GABAA receptor-mediated currents and could be inhibited with the GABAA receptor blocker Gabazine (Gbz) (12.5 μM).

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    Gabazine free base purchased from MedChemExpress. Usage Cited in: Elife. 2024 May 29.

    Customer Validation
     The effects of ICV injection of different doses of Gabazine (2 or 4 μg/mL; 2000 nL) on the recovery time of midazolam. Compared with the vehicle, ICV injection of Gabazine could reduce the recovery time.

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    Gabazine free base purchased from MedChemExpress. Usage Cited in: Elife. 2024 May 29.

    Customer Validation
     The peak ΔF/F in the Before RORR and RORR-Recovery stages with or without intracerebroventricular injection of Gabazine (4 μg/mL). Gabazine could increase the ΔF/F peak of calcium signaling in LCNE neurons.

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    Gabazine free base purchased from MedChemExpress. Usage Cited in: Elife. 2024 May 29.

    Customer Validation
     The effects of intra-LC injection of Gabazine (4 μg/mL)and intra-VLPO injection of prazosin on the recovery time of midazolam. Microinjection of Gabazine into the LC could reduce the recovery time.

  • Gabazine free base