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Hepa 1c1c7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aryl Hydrocarbon Receptor (1) Bacterial (1) Cytochrome P450 (3) Interleukin Related (1) Keap1-Nrf2 (1) Quinone Reductase (4)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147128

PY109	Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related	Inflammation/Immunology
PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC₅₀ values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis .

HY-N10344

Glucoarabin	Cytochrome P450 Quinone Reductase	Cancer
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .

HY-N6802

Tigloylgomisin H	Keap1-Nrf2	Cancer
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .

HY-167694

Antiproliferative agent-62	Quinone Reductase	Cancer
Antiproliferative agent-62 (compound 5) is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity and NQO1 activity induciton funciton, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116.

HY-N17587

3,24-Diacetate barbinervic acid	Others	Others
3,24-Diacetate barbinervic acid is a triterpenoid derivative found in the stems of Coussarea brevicaulis .

HY-N11855

Casimiroin	Quinone Reductase Cytochrome P450 Bacterial	Infection Cancer
Casimiroin is a QR2 and Aromatase inhibitor, with an IC₅₀ of 54.1 μM against QR2 and an IC₅₀ of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research .

HY-177543

5-(4-Methoxvphenol)-4-methyl-3H-1,2-dithiole-3-thione	Quinone Reductase	Others
5-(4-Methoxyphenol)-4-methyl-3H-1,2-dithiole-3-thione is a Phase 2 enzyme inducer. 5-(4-Methoxyphenol)-4-methyl-3H-1,2-dithiole-3-thione induces the activity of NAD (P) H:quinone oxidoreductase (QR; NQO1) in hepatoma cells. 5-(4-Methoxyphenol)-4-methyl-3H-1,2-dithiole-3-thione enhances growth hormone production in plasmid-transfected hepatoma cells .

Glucoarabin	Natural Products Classification of Application Fields Camelina sativa (L.) Crantz Glucosinolates Plants Brassicaceae Disease Research Fields Source Classification Cancer	Cytochrome P450 Quinone Reductase
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .

Tigloylgomisin H	Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Source Classification Cancer	Keap1-Nrf2
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .

3,24-Diacetate barbinervic acid	Structural Classification Coussarea brevicaulis K.Krause Terpenoids Rubiaceae Plants Pentacyclic Triterpenoids Source Classification	Others
3,24-Diacetate barbinervic acid is a triterpenoid derivative found in the stems of Coussarea brevicaulis .

Casimiroin	Structural Classification Natural Products Ketones, Aldehydes, Acids Casimiroa edulis La Llave Rutaceae Plants Source Classification	Quinone Reductase Cytochrome P450 Bacterial
Casimiroin is a QR2 and Aromatase inhibitor, with an IC₅₀ of 54.1 μM against QR2 and an IC₅₀ of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Hepa 1c1c7

Inhibitors & Agonists

NaturalProducts

Natural
Products