Antiproliferative agent-62
Antiproliferative agent-62 (compound 5) is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity and NQO1 activity induciton funciton, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116.
For research use only. We do not sell to patients.
- CAS No.: 856435-40-0
- Formula: C17H15NO3
- Molecular Weight:281.31
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
52.5 μM
Compound: 1b
|
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 24852275] |
| HCT-116 | GI50 |
13.42 μM
Compound: 1b
|
Antiproliferative activity against human HCT116 cells expressing wild type p53 after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells expressing wild type p53 after 48 hrs by MTT assay
|
[PMID: 24852275] |
| HCT-116 | GI50 |
28.14 μM
Compound: 1b
|
Antiproliferative activity against p53-deficient human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against p53-deficient human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 24852275] |
| HCT-116 | IC50 |
8.8 μM
Compound: 5
|
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
|
[PMID: 19200740] |
| MCF7 | GI50 |
54.13 μM
Compound: 1b
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 24852275] |
| MCF7 | IC50 |
3.3 μM
Compound: 5
|
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 19200740] |
Chemical Information
-
CAS No. 856435-40-0
-
Molecular Weight 281.31
-
Formula C17H15NO3
-
SMILES
O=C1NC2=CC=CC=C2/C1=C\C3=C(C=C(C=C3)OC)OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)