2. Metabolic Enzyme/Protease
  3. Quinone Reductase
  4. Antiproliferative agent-62

Antiproliferative agent-62 (compound 5) is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity and NQO1 activity induciton funciton, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116.

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Antiproliferative agent-62

Antiproliferative agent-62 Chemical Structure

CAS No. : 856435-40-0

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Antiproliferative agent-62 Related Antibodies

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Description

Antiproliferative agent-62 (compound 5) is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity and NQO1 activity induciton funciton, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116.

Cellular Effect
Cell Line Type Value Description References
A549 GI50
52.5 μM
Compound: 1b
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 24852275]
HCT-116 GI50
13.42 μM
Compound: 1b
Antiproliferative activity against human HCT116 cells expressing wild type p53 after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells expressing wild type p53 after 48 hrs by MTT assay
[PMID: 24852275]
HCT-116 GI50
28.14 μM
Compound: 1b
Antiproliferative activity against p53-deficient human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against p53-deficient human HCT116 cells after 48 hrs by MTT assay
[PMID: 24852275]
HCT-116 IC50
8.8 μM
Compound: 5
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 19200740]
MCF7 GI50
54.13 μM
Compound: 1b
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24852275]
MCF7 IC50
3.3 μM
Compound: 5
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 19200740]
Molecular Weight

281.31

Formula

C17H15NO3
CAS No.
SMILES

O=C1NC2=CC=CC=C2/C1=C\C3=C(C=C(C=C3)OC)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-62 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-62856435-40-0Antiproliferative agent62Antiproliferative agent 62Quinone ReductaseInhibitorinhibitorinhibit

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