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Results for "

KDM5C

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

1

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120400
    KDM5-C70
    5+ Cited Publications

    		 Histone Demethylase Cancer
    KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels .
    KDM5-C70
  • HY-102047B
    KDOAM-25 citrate
    Maximum Cited Publications
    9 Publications Verification

    		 Histone Demethylase Cancer
    KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .
    KDOAM-25 citrate
  • HY-119397A
    KDM5-C49 hydrochloride
    1 Publications Verification

    KDOAM-20 hydrochloride

    		 Histone Demethylase Cancer
    KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 hydrochloride can be used for the research of cancer .
    KDM5-C49 hydrochloride
  • HY-100014
    KDM5A-IN-1
    4 Publications Verification

    		 Histone Demethylase Cancer
    KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B) .
    KDM5A-IN-1
  • HY-100764
    YUKA1
    1 Publications Verification

    		 Histone Demethylase Cancer
    YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers .
    YUKA1
  • HY-RS07220
    KDM5C Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KDM5C Human Pre-designed siRNA Set A contains three designed siRNAs for KDM5C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KDM5C Human Pre-designed siRNA Set A
    KDM5C Human Pre-designed siRNA Set A
  • HY-102047
    KDOAM-25

    		Histone Demethylase Cancer
    KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .
    KDOAM-25
  • HY-119397
    KDM5-C49

    KDOAM-20

    		 Histone Demethylase Cancer
    KDM5-C49 (KDOAM-20) is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 can be used for the research of cancer .
    KDM5-C49
  • HY-RS16858
    Kdm5c Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kdm5c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm5c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kdm5c Mouse Pre-designed siRNA Set A
    Kdm5c Mouse Pre-designed siRNA Set A
  • HY-RS23299
    Kdm5c Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kdm5c Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm5c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kdm5c Rat Pre-designed siRNA Set A
    Kdm5c Rat Pre-designed siRNA Set A
  • HY-102047A
    KDOAM-25 trihydrochloride

    		Histone Demethylase Cancer
    KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .
    KDOAM-25 trihydrochloride
  • HY-100764R
    YUKA1 (Standard)

    		Histone Demethylase Reference Standards Cancer
    YUKA1 (Standard) is the analytical standard of YUKA1 (HY-100764). This product is intended for research and analytical applications. YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers .
    YUKA1 (Standard)
  • HY-183618
    DW-229

    		PROTACs Histone Demethylase Cancer
    DW-229 is a PROTAC degrader derived from Deferiprone (HY-B0568), targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs). DW-229 degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells. DW-229 shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. DW-229 can be used for the research of breast cancer, liver cancer, prostate cancer, lung cancer .
    DW-229
  • HY-100014R
    KDM5A-IN-1 (Standard)

    		Histone Demethylase Reference Standards Cancer
    KDM5A-IN-1 (Standard) is the analytical standard of KDM5A-IN-1 (HY-100014). This product is intended for research and analytical applications. KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B) .
    KDM5A-IN-1 (Standard)

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