1. Epigenetics
  2. Histone Demethylase
  3. KDOAM-25 trihydrochloride

KDOAM-25 trihydrochloride 

Cat. No.: HY-102047A
Handling Instructions

KDOAM-25 trihydrochloride is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.

For research use only. We do not sell to patients.

KDOAM-25 trihydrochloride Chemical Structure

KDOAM-25 trihydrochloride Chemical Structure

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Description

KDOAM-25 trihydrochloride is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].

IC50 & Target

IC50: 71 nM (KDM5A), 19 nM (KDM5B), 69 nM (KDM5C), 69 nM (KDM5D)[1]

Molecular Weight

416.77

Formula

C₁₅H₂₈Cl₃N₅O₂

SMILES

NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.Cl.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KDOAM-25 trihydrochlorideHistone DemethylaseInhibitorinhibitorinhibit

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KDOAM-25 trihydrochloride
Cat. No.:
HY-102047A
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