KDM5C/Jarid1C/SMCX Antibody (YA5159)
(Synonyms: KDM5C; DXS1272E; JARID1C; SMCX; XE169; Lysine-specific demethylase 5C; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169)KDM5C/Jarid1C/SMCX Antibody (YA5159) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM5C/Jarid1C/SMCX.
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Host:
Mouse
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat, Bovine, Dog
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:500 |
Product Details
KDM5C/Jarid1C/SMCX Antibody (YA5159) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM5C/Jarid1C/SMCX.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat, Bovine, Dog
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Calculated Molecular Weight Predicted band size: 176 kDa;
Purified recombinant human SmcX (C-terminus) protein fragments expressed in E.coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KDM5C/Jarid1C/SMCX is a Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:It was expressed in all tissues tested. The highest levels were found in the brain and skeletal muscle. -
Isoforms & Post-Translational Modification
P41229 has 5 isomers: P41229-1: 175720 Da (predicted); P41229-2: 175379 Da (predicted); P41229-3: 170561 Da (predicted); P41229-4: 155119 Da (predicted); P41229-5: 175592 Da (predicted).
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Subunit
Part of two distinct complexes, one containing E2F6, and the other containing REST (PubMed:17468742). Interacts with ZMYND8 (PubMed:33323928)
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SwissProt ID
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Synonyms
KDM5C; DXS1272E; JARID1C; SMCX; XE169; Lysine-specific demethylase 5C; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169
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