1. Epigenetics
  2. Histone Demethylase
  3. YUKA1

YUKA1 

Cat. No.: HY-100764
Handling Instructions

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity.

For research use only. We do not sell to patients.

YUKA1 Chemical Structure

YUKA1 Chemical Structure

CAS No. : 708991-09-7

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Description

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].

IC50 & Target

IC50: 2.66 μM (KDM5A), 7.12 μM (KDM5C)[1]

Molecular Weight

292.36

Formula

C₁₃H₁₆N₄O₂S

CAS No.

708991-09-7

SMILES

C=CCOC1=C(CNN2C(S)=NN=C2)C=CC=C1OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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YUKA1
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HY-100764
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