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  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. KDM5C/Jarid1C/SMCX Antibody (YA1063)

KDM5C/Jarid1C/SMCX Antibody (YA1063)

Art. -Nr.: HY-P81318
COA
SDS
User Guide for Antibodies Technical Support

KDM5C/Jarid1C/SMCX Antibody (YA1063) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KDM5C/Jarid1C/SMCX.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Verification Image

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  • Beschreibung

Beschreibung

KDM5C/Jarid1C/SMCX Antibody (YA1063) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KDM5C/Jarid1C/SMCX.
Host

Mouse
Clonality

Monoclonal
Molekulargewicht
Predicted band size: 176 kDa;
Observed band size: 220 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Reinheit Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG2a  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Verification Image
WB

  • Western blot analysis was performed on extracts from 293T (lane 1, 15 μg), Hela (lane 2, 15 μg), Jurkat (lane 3, 15 μg), and A431 (lane 4, 15 μg) using KDM5C Mouse mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P80438, 1:5000 dilution) was incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Mouse IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

Background
Function：Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)
Subcellular Localization：Nucleus
Expression：
Tissue_specificity:It was expressed in all tissues tested. The highest levels were found in the brain and skeletal muscle.
Isoforms & Post-Translational Modification：P41229 has 5 isomers: P41229-1: 175720 Da (predicted); P41229-2: 175379 Da (predicted); P41229-3: 170561 Da (predicted); P41229-4: 155119 Da (predicted); P41229-5: 175592 Da (predicted).
Subunit：Part of two distinct complexes, one containing E2F6, and the other containing REST (PubMed:17468742). Interacts with ZMYND8 (PubMed:33323928)
Database

Entrez Gene: 8242 Human

SwissProt: P41229 Human

OMIM: 300534 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
MRXJ; SMCX; MRXSJ; XE169; MRXSCJ; JARID1C; DXS1272E
Dokumentation
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

KDM5C/Jarid1C/SMCX Antibody (YA1063) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KDM5C/Jarid1C/SMCX Antibody (YA1063)
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