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NED

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arginase (1) Calcium Channel (5) Fluorescent Dye (1) mRNA (1) Reference Standards (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (4) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	mRNA (1) Interleukin & Receptors (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103316

*trans-Ned* 19**	Calcium Channel	Cardiovascular Disease Inflammation/Immunology
trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis .

HY-103316A

Ned 19 3 Publications Verification	Calcium Channel	Cardiovascular Disease Cancer
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca ²⁺ signaling, with an IC₅₀ of 65 nM . Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice .

HY-174631

Human IL18 mRNA	mRNA	Inflammation/Immunology
Human IL18 mRNA encodes the human interleukin 18 (IL18) protein, a proinflammatory cytokine of the IL-1 family. IL18 is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm.

HY-126332

NED-3238	Arginase	Metabolic Disease
NED-3238 is a highly potent arginase I and II inhibitor with IC₅₀ values of 1.3 nM and 8.1 nM, respectively .

HY-103305

*cis-Ned19*	Fluorescent Dye Calcium Channel	Others
cis-Ned19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. cis-Ned19 localizes to lysosomes and endolysosomal vesicles, stains two-pore calcium channels and fluorescently labels NAADP receptors (Ex/Em = 365/410 nm) .

HY-131041

Ned-K	Calcium Channel	Cardiovascular Disease
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca ²⁺ oscillations in cardiomyocytes .

HY-103316R

*trans-Ned* 19 (Standard)**	Reference Standards Calcium Channel	Cardiovascular Disease Inflammation/Immunology
trans-Ned 19 (Standard) is the analytical standard of trans-Ned 19 (HY-103316). This product is intended for research and analytical applications. trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701595

	NEDD4L Protein, Human NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; NEDd4-2	Human	E. coli
	The NEDD4L protein is an E3 ubiquitin protein ligase that regulates multiple signaling pathways, including autophagy, innate immunity, and DNA repair. NEDD4L Protein, Human is the recombinant human-derived NEDD4L protein, expressed by E. coli , with tag free.

HY-P701596

	NEDD4L Protein, Human (His) NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; NEDd4-2	Human	E. coli
	The NEDD4L protein is an E3 ubiquitin protein ligase that regulates multiple signaling pathways, including autophagy, innate immunity, and DNA repair. NEDD4L Protein, Human (His) is the recombinant human-derived NEDD4L protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (1)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80240

	NEDD8 Antibody (YA273) FLJ43224 antibody; MGC104393 antibody; MGC125896 antibody; MGC125897 antibody; NED8 antibody; NEDD 8 antibody; NEDD-8 antibody; NEDd8 antibody; NEDD8_HUMAN antibody; NEDdylin antibody; Neural precursor cell expressed developmentally down regulated 8 antibody; Neural precursor cell expressed developmentally down regulated gene 8 antibody; Neural precursor cell expressed developmentally down-regulated protein 8 antibody; Rub1 antibody; Ubiquitin like protein NEDd 8 antibody; Ubiquitin like protein NEDd8 antibody; Ubiquitin-like protein NEDd8 antibody;	WB, ICC/IF, IHC-P, IP	Human, Rat
	NEDD8 Antibody (YA273) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEDD8.

HY-P86985

	NEDD4L Antibody (YA6678) E3 ubiquitin protein ligase NEDD4 like protein antibody; E3 ubiquitin-protein ligase NEDD4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; NEDD4 2 antibody; NEDD4-2 antibody; NEDD4 2c antibody; NEDd4-2 antibody; NEDD4-2a antibody; NEDD4.2 antibody; E3 ubiquitin protein ligase NEDD4 like protein antibody; E3 ubiquitin-protein ligase NEDD4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; NEDD4 2 antibody; NEDD4-2 antibody; NEDD4 2c antibody; NEDd4-2 antibody; NEDD4-2a antibody; NEDD4.2 antibody; NEDD4b antibody; NEDD4L antibody; NEDD4La antibody; NEDD4Lb antibody; NEDD4Lc antibody; NEDD4Ld antibody; NEDD4Le antibody; NEDD4Lf antibody; NEDD4Lg antibody; NEDD4Lh antibody; NEDL3 antibody; Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody; Neural precursor cell expressed, developmentally down regulated 4 like antibody; RSP5 antibody; Ubiquitin protein ligase Rsp5 antibody;	WB, IP	Human
	NEDD4L Antibody (YA6678) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEDD4L.

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Cat. No.	Product Name		Classification

HY-174631

Human IL18 mRNA		mRNA Interleukin & Receptors
Human IL18 mRNA encodes the human interleukin 18 (IL18) protein, a proinflammatory cytokine of the IL-1 family. IL18 is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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