1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. trans-Ned 19

trans-Ned 19 

Cat. No.: HY-103316 Purity: 99.53%
Handling Instructions

trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations.

For research use only. We do not sell to patients.

trans-Ned 19 Chemical Structure

trans-Ned 19 Chemical Structure

CAS No. : 1354235-96-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 221 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 221 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 195 In-stock
Estimated Time of Arrival: December 31
10 mg USD 295 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of trans-Ned 19:

Top Publications Citing Use of Products
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Description

trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].

IC50 & Target[1]

Ca2+

 

Molecular Weight

514.59

Formula

C30H31FN4O3

CAS No.
SMILES

O=C([[email protected]@H]1CC2=C([[email protected]@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (242.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9433 mL 9.7165 mL 19.4329 mL
5 mM 0.3887 mL 1.9433 mL 3.8866 mL
10 mM 0.1943 mL 0.9716 mL 1.9433 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (12.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (12.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (12.15 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
trans-Ned 19
Cat. No.:
HY-103316
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