1354235-96-3
Chemical Structure
trans-Ned 19
- CAS No.: 1354235-96-3
- Formula:C30H31FN4O3
- Molecular Weight:514.59
IUPAC Name: (1R,3S)-1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
InChIKey: FUHCEERDBRGPQZ-LBNVMWSVSA-N
SMILES: O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O
Biological Activity: trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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trans-Ned 19 | 99.33% | trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis. | ||||||||||||||||||||
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trans-Ned 19 (Standard) | ≥98% | trans-Ned 19 (Standard) is the analytical standard of trans-Ned 19 (HY-103316). This product is intended for research and analytical applications. trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis. | ||||||||||||||||||||
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References
- [1]. Nawrocki M, et al. Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice. Cells. 2021 Nov 5;10(11):3039. [Content Brief]
- [2]. Trufanov SK, et al. The Role of Two-Pore Channels in Norepinephrine-Induced [Ca2+]i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. Cells. 2019 Sep 25;8(10):1144. [Content Brief]
- [3]. Goretzko J, et al. Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2). bioRxiv, 2021: 2021.09. 28.462104.
- [4]. Nawrocki M. Adenine dinucleotide Ca2+ mobilizing second messengers modulate CD4+ T-cells differentiation and effector function. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky, 2021.
- [5]. Arndt L, et al. NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol Biol Cell. 2014 Mar;25(6):948-64. [Content Brief]
- [6]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438. [Content Brief]
