PP2B

By Targets:	Antibiotic (4) Bacterial (3) Complement System (4) Cyclophilin (4) Environmental Pollutants (1) Isotope-Labeled Compounds (5) Molecular Glues (7) Phosphatase (6) Reference Standards (3)
By Research Areas:	Cancer (3) Infection (4) Inflammation/Immunology (8) Neurological Disease (1)

Targets Recommended: Calcineurin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0579

Cyclosporin A 185+ Cited Publications Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Complement System Antibiotic Cyclophilin	Infection Neurological Disease Inflammation/Immunology Cancer
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-106638

Voclosporin 1 Publications Verification ISAtx-247	Molecular Glues Phosphatase	Inflammation/Immunology
Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor .

HY-B2006

Fenvalerate	Environmental Pollutants Phosphatase Bacterial	Infection
Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC₅₀ of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide .

HY-B0579R

Cyclosporin A (Standard) Cyclosporine A (Standard); Ciclosporin A (Standard); CsA (Standard)	Molecular Glues Reference Standards Complement System Antibiotic Cyclophilin	Inflammation/Immunology Cancer
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S3

Cyclosporin A-13C2,d4 Cyclosporine A-¹³C₂,d₄; Ciclosporin A-¹³C₂,d₄; CsA-¹³C₂,d₄	Isotope-Labeled Compounds	Inflammation/Immunology
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM ^[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-106638R

Voclosporin (Standard) ISAtx-247 (Standard)	Molecular Glues Reference Standards Phosphatase	Inflammation/Immunology
Voclosporin (Standard) is the analytical standard of Voclosporin. This product is intended for research and analytical applications. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor .

HY-B0579S5

Cyclosporin A-d12 Cyclosporine A-d₁₂; Ciclosporin A-d₁₂; CsA-d₁₂	Isotope-Labeled Compounds Complement System Antibiotic Cyclophilin Molecular Glues	Inflammation/Immunology Cancer
Cyclosporin A-d₁₂ (Cyclosporine A-d₁₂) is deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S2

Cyclosporin A acetate-d4 Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄; CsA acetate-d₄	Isotope-Labeled Compounds Antibiotic Complement System Molecular Glues Cyclophilin	Inflammation/Immunology
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM ^[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-106638S

Voclosporin-d4 ISAtx-247-d₄	Isotope-Labeled Compounds Phosphatase Molecular Glues	Inflammation/Immunology
Voclosporin-d₄ (ISAtx-247-d₄) is deuterium labeled Voclosporin. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor .

HY-B2006S

Fenvalerate-d5	Isotope-Labeled Compounds Phosphatase Bacterial	Infection
Fenvalerate-d₅ is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC₅₀ of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide .

HY-B2006R

Fenvalerate (Standard)	Reference Standards Phosphatase Bacterial	Infection
Fenvalerate (Standard) is the analytical standard of Fenvalerate. This product is intended for research and analytical applications. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC₅₀ of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library	175 compounds
Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc. Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action. MCE supplies a unique collection of 175 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Phosphatase Inhibitor Library

175 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 175 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-B0579

Cyclosporin A 185+ Cited Publications Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Complement System Antibiotic Cyclophilin	Infection Neurological Disease Inflammation/Immunology Cancer
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0579

Cyclosporin A 185+ Cited Publications Cyclosporine A; Ciclosporin A; CsA	Structural Classification Natural Products Microorganisms Classification of Application Fields Anti-aging Inflammation/Immunology Disease Research Fields Source Classification Cancer	Molecular Glues Complement System Antibiotic Cyclophilin
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579R

Cyclosporin A (Standard) Cyclosporine A (Standard); Ciclosporin A (Standard); CsA (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Molecular Glues Reference Standards Complement System Antibiotic Cyclophilin
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

Cat. No.	Product Name	Chemical Structure

HY-B0579S3

Cyclosporin A-13C2,d4
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM ^[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S5

Cyclosporin A-d12
Cyclosporin A-d₁₂ (Cyclosporine A-d₁₂) is deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S2

Cyclosporin A acetate-d4
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM ^[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-106638S

Voclosporin-d4
Voclosporin-d₄ (ISAtx-247-d₄) is deuterium labeled Voclosporin. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor .

HY-B2006S

Fenvalerate-d5
Fenvalerate-d₅ is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC₅₀ of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide .

Host:	Mouse (2)
Reactivity:	mouse (1) rat (1) human (2)
Application:	ICC/IF (1) IF-Tissue (1) IP (2) WB (2) ELISA (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89890

	PP2B-Aγ Antibody (YA9234)	WB, IP, ELISA	human
	PP2B-Aγ Antibody (YA9234) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PP2B-Aγ.

HY-P89880

	PP2B-B1 Antibody (YA9224)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	PP2B-B1 Antibody (YA9224) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PP2B-B1.

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PP2B

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