Fenvalerate-d5
Based on 1 Customer Validation
Fenvalerate-d5 is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide.
For research use only. We do not sell to patients.
- Purity : 97.01%
- CAS No.: 1246815-00-8
- Formula: C25H17D5ClNO3
- Molecular Weight:424.93
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246815-00-8
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Unlabeled CAS 51630-58-1
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Appearance Oil
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Molecular Weight 424.93
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Formula C25H17D5ClNO3
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Color Colorless to light yellow
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SMILES
CC(C)C(C1=CC=C(Cl)C=C1)C(OC(C#N)C2=CC=CC(OC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (117.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (625 KB)
- English - EN (625 KB)
- Français - FR (625 KB)
- Deutsch - DE (625 KB)
- Norwegian - NO (625 KB)
- Español - ES (625 KB)
- Swedish - SV (625 KB)
- Italian - IT (625 KB)
- Korean - KR (625 KB)
- Portuguese - PT (625 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. E Enan, et al. Specific Inhibition of Calcineurin by Type II Synthetic Pyrethroid Insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84.;A R Reilein, et al. Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A). J Cell Biol. 1998 Aug 10;142(3):803-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3533 mL | 11.7666 mL | 23.5333 mL | 58.8332 mL |
| 5 mM | 0.4707 mL | 2.3533 mL | 4.7067 mL | 11.7666 mL | |
| 10 mM | 0.2353 mL | 1.1767 mL | 2.3533 mL | 5.8833 mL | |
| 15 mM | 0.1569 mL | 0.7844 mL | 1.5689 mL | 3.9222 mL | |
| 20 mM | 0.1177 mL | 0.5883 mL | 1.1767 mL | 2.9417 mL | |
| 25 mM | 0.0941 mL | 0.4707 mL | 0.9413 mL | 2.3533 mL | |
| 30 mM | 0.0784 mL | 0.3922 mL | 0.7844 mL | 1.9611 mL | |
| 40 mM | 0.0588 mL | 0.2942 mL | 0.5883 mL | 1.4708 mL | |
| 50 mM | 0.0471 mL | 0.2353 mL | 0.4707 mL | 1.1767 mL | |
| 60 mM | 0.0392 mL | 0.1961 mL | 0.3922 mL | 0.9806 mL | |
| 80 mM | 0.0294 mL | 0.1471 mL | 0.2942 mL | 0.7354 mL | |
| 100 mM | 0.0235 mL | 0.1177 mL | 0.2353 mL | 0.5883 mL |
Fenvalerate-d5 Related Classifications
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