1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Voclosporin

Voclosporin (Synonyms: ISAtx-247)

Cat. No.: HY-106638 Purity: 99.20%
Handling Instructions

Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.

For research use only. We do not sell to patients.

Voclosporin Chemical Structure

Voclosporin Chemical Structure

CAS No. : 515814-01-4

Size Price Stock Quantity
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor[1].

IC50 & Target


In Vitro

This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay[1]. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight





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Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (41.17 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8233 mL 4.1165 mL 8.2330 mL
5 mM 0.1647 mL 0.8233 mL 1.6466 mL
10 mM 0.0823 mL 0.4117 mL 0.8233 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
Animal Administration

Wild-caught, male cynomolgus monkeys, weighing between 5 and 8 kg, are used. Four groups of animals are treated twice daily at 8:00 AM and 6:00 PM for 7 days with the following doses: Group I (n=6), Voclosporin 25 mg/kg; Group II (n=6), Voclosporin 50 mg/kg; Group III (n=5), CsA 25 mg/kg; and Group IV (n=4), vehicle (no drug) 1 mL/kg. Levels of Cyclosporine and Voclosporin in whole blood are measured by liquid chromatography/mass spectrometry[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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VoclosporinISAtx-247ISAtx247ISAtx 247PhosphataseInhibitorinhibitorinhibit

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