1. Others
  2. Others

Voclosporin (Synonyms: ISAtx-247)

Cat. No.: HY-106638 Purity: 99.20%
Handling Instructions

Voclosporin is a calcineurin (CN) inhibitor.

For research use only. We do not sell to patients.

Voclosporin Chemical Structure

Voclosporin Chemical Structure

CAS No. : 515814-01-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1269 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Voclosporin is a calcineurin (CN) inhibitor.

IC50 & Target

Calcineurin[1]

In Vitro

This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay[1]. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro[2].

In Vivo

All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively)[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8233 mL 4.1165 mL 8.2330 mL
5 mM 0.1647 mL 0.8233 mL 1.6466 mL
10 mM 0.0823 mL 0.4117 mL 0.8233 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Monkey[2]
Wild-caught, male cynomolgus monkeys, weighing between 5 and 8 kg, are used. Four groups of animals are treated twice daily at 8:00 AM and 6:00 PM for 7 days with the following doses: Group I (n=6), Voclosporin 25 mg/kg; Group II (n=6), Voclosporin 50 mg/kg; Group III (n=5), CsA 25 mg/kg; and Group IV (n=4), vehicle (no drug) 1 mL/kg. Levels of Cyclosporine and Voclosporin in whole blood are measured by liquid chromatography/mass spectrometry[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1214.62

Formula

C₆₃H₁₁₁N₁₁O₁₂

CAS No.

515814-01-4

SMILES

C=C/C=C/C[[email protected]@H](C)[[email protected]]([[email protected]]1([H])N(C([[email protected]](N(C([[email protected]@H](N(C([[email protected]](N(C([[email protected]](NC([[email protected]@H](NC([[email protected]](CC(C)C)N(C)C([[email protected]@](C(C)C)([H])NC([[email protected]](CC(C)C)N(C)C(CN(C)C([[email protected]](CC)NC1=O)=O)=O)=O)=O)=O)C)=O)C)=O)C)([H])CC(C)C)=O)C)CC(C)C)=O)C)([H])C(C)C)=O)C)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Voclosporin
Cat. No.:
HY-106638
Quantity:

Voclosporin

Cat. No.: HY-106638