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SARS-CoV-2-IN-14

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144771
    SARS-CoV-2-IN-14

    		SARS-CoV Infection
    SARS-CoV-2-IN-14 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.39 μM. SARS-CoV-2-IN-14 is a niclosamide analogue. SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally .
    SARS-CoV-2-IN-14
  • HY-179048
    MH44

    		DNA Methyltransferase SARS-CoV Infection
    MH44 is an efficient inhibitor targeting the SARS-CoV-2 nsp14 N7-methyltransferase (N7-MTase) with an IC50 of 19 nM. MH44 exhibits moderate antiviral effects in SARS-CoV-2-infected A549-hACE2 cells and shows certain cytotoxicity at higher concentrations. MH44 can be used in the research on anti-SARS-CoV-2 .
    MH44
  • HY-150681
    SARS-CoV-2 nsp14-IN-2

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-2 is a potent SARS-CoV-2 Nsp14 methyltransferase inhibitor with an IC50 value of 0.093 µM. SARS-CoV-2 nsp14-IN-2 shows antiviral activity. SARS-CoV-2 nsp14-IN-2 shows plasma and liver S9 stability. SARS-CoV-2 nsp14-IN-2 has the potential for the research of COVID-19 .
    SARS-CoV-2 nsp14-IN-2
  • HY-155679
    SARS-CoV-2 nsp14-IN-4

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-4 (Compound 12q) is an inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50=19 nM). SARS-CoV-2 nsp14-IN-4 is non-cytotoxic and cell-permeable. SARS-CoV-2 nsp14-IN-4 is used in COVID-19 research .
    SARS-CoV-2 nsp14-IN-4
  • HY-149321
    SARS-CoV-2 nsp14-IN-3

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-3 (4975) is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC50: 3.5 μM) .
    SARS-CoV-2 nsp14-IN-3
  • HY-153719
    NSC111552

    		SARS-CoV Infection
    NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC50 of 5.1 μM .
    NSC111552
  • HY-150680
    SARS-CoV-2 nsp14-IN-1

    		SARS-CoV Histone Methyltransferase DNA Methyltransferase Infection
    SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases .
    SARS-CoV-2 nsp14-IN-1
  • HY-163211
    SARS-CoV-2 Mpro-IN-14

    		SARS-CoV Infection
    SARS-CoV-2 Mpro-IN-14 (Compound 19) is an inhibitor of SARS-CoV-2 Mpro with an IC50 of 0.044 μM. SARS-CoV-2 Mpro-IN-14 exhibits water solubility, has no cytotoxicity, and can be used in the study of COVID-19 .
    SARS-CoV-2 Mpro-IN-14
  • HY-149317
    ZINC475239213

    		SARS-CoV Infection
    ZINC475239213 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC50: 20 μM) .
    ZINC475239213
  • HY-149319
    ZINC61142882

    		SARS-CoV Infection
    ZINC61142882 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC50: 6 μM) .
    ZINC61142882
  • HY-149322
    Z795161988

    		SARS-CoV Infection
    Z795161988 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC50: 2.2 μM) .
    Z795161988
  • HY-149320
    Acryl42-10

    		SARS-CoV Infection
    Acryl42-10 is a covalent inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC50: 7 μM) .
    Acryl42-10
  • HY-159890
    MTI013

    		SARS-CoV Infection
    MTI013 is a selective SARS-CoV-2 nsp14 Mtase inhibitor (IC50: 2.98 μM) and an antiviral agent (IC50: 10.33 μM in HCoV-229E-infected Huh7 cells). MTI013 also shows a synergistic antiviral effect with the RdRp inhibitor SHEN26 (HY-155488) .
    MTI013
  • HY-178027
    SARS-CoV-2 nsp14-IN-6

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-6 (Compound 35) is a SARS-CoV-2 Nsp14 MTase inhibitor with an IC50 of 0.24  μM. SARS-CoV-2 nsp14-IN-6 has potent antiviral activity against SARS-CoV-2 replication. SARS-CoV-2 nsp14-IN-6 increases lipophilicity, further improving cell permeability. SARS-CoV-2 nsp14-IN-6 can be used for human coronaviruses research .
    SARS-CoV-2 nsp14-IN-6
  • HY-178027A
    SARS-CoV-2 nsp14-IN-6 ammonium

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-6 (Compound 35) ammonium is a SARS-CoV-2 Nsp14 MTase inhibitor with an IC50 of 0.24  μM. SARS-CoV-2 nsp14-IN-6 ammonium has potent antiviral activity against SARS-CoV-2 replication. SARS-CoV-2 nsp14-IN-6 ammonium increases lipophilicity, further improving cell permeability. SARS-CoV-2 nsp14-IN-6 ammonium can be used for human coronaviruses research .
    SARS-CoV-2 nsp14-IN-6 ammonium
  • HY-179097
    SARS-CoV-2 nsp14-IN-8

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-8 (Compound 26) is a SARS-CoV-2 nsp14 inhibitor, with an IC50 of 53 nM. SARS-CoV-2 nsp14-IN-8 shows IC50 values of 170 nM, 8 nM, 21 nM against SARS-CoV-1 nsp14, HCoV-NL63 nsp14, HCoV-229E nsp14, respectively. SARS-CoV-2 nsp14-IN-8 can be used in the research of Coronavirus infection .
    SARS-CoV-2 nsp14-IN-8
  • HY-179556
    SARS-CoV-2 nsp14-IN-10

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-10 is a highly potent and selective NSP14 (IC50 = 0.34 µM) S-adenosylmethionine (SAM) binding pocket inhibitor. SARS-CoV-2 nsp14-IN-10 demonstrates robust antiviral activity against SARS-CoV-2. SARS-CoV-2 nsp14-IN-10 exhibits broad-spectrum activity against other betacoronaviruses and inhibits SARS-CoV-2 at the replication stage. SARS-CoV-2 nsp14-IN-10 suppresses viral translation and exhibits immunostimulatory effects. SARS-CoV-2 nsp14-IN-10 specifically reverses NSP14-mediated alterations inhost transcriptome. SARS-CoV-2 nsp14-IN-10 can be used for the study of SARS-CoV-2 .
    SARS-CoV-2 nsp14-IN-10
  • HY-180126
    SARS-CoV-2 nsp14-IN-11

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-11 (Compound 13) is a NSP14 exonuclease inhibitor (pIC50 = 4.4). SARS-CoV-2 nsp14-IN-11 shows robust and complete NSP14 exonuclease inhibition. SARS-CoV-2 nsp14-IN-11 can be used in the research of SARS-CoV-2 infection .
    SARS-CoV-2 nsp14-IN-11
  • HY-179269
    SARS-CoV-2 nsp14-IN-9

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-9 (Compound 4P) is a selective nsp14 inhibitor with an IC50 of 0.20 μM. SARS-CoV-2 nsp14-IN-9 inhibits both mouse hepatitis virus and SARS-CoV-2 replication .
    SARS-CoV-2 nsp14-IN-9

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